English

Profile

Mayumi Ueta, M.D., Ph.D.,
Associate Professor
Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Name,Family name: UETA
Forename: MAYUMI
Sex: Female
Nationality: Japanese

Present address (Mailing address):
Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine,
465 Kajiicho, Hirokoji, Kawaramachi, Kamigyoku, Kyoto 602-0841, Japan
Phone: 81-75-251-5578, Fax: 81-75-251-5663, e-mail: mueta@koto.kpu-m.ac.jp

Education and Research Experience

1990 M.D., Graduated from Kochi Medical School
1999 Graduate student, Kyoto Prefectural University of Medicine
2000 Reseach fellow, Research Institute for Microbial Diseases, Osaka University
2003 Ph.D., Kyoto Prefectural University of Medicine
2004 Department of Ophthalmology, Kyoto Prefectural University of Medicine
2008~2011 Assistant Professor, Research Center for Inflammation and Regenerative Medicine, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
2010~ guest lecturer of Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
2010 Guest Researcher, NIH, USA
2011~2015 Associate Professor, Research Center for Inflammation and Regenerative Medicine, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
2011~2014 Visiting Teacher, Osaka University, Kyoto, Japan.
2012~ Visiting Reseacher, Graduate School of Medicine, University of Tokyo, Japan
2015.4 ~ Associate Professor, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Publicaiton

Book

  1. Risa Tamagawa-Mineoka, Mayumi Ueta, and Norito Katoh. TLR3 and Inflammatory Skin Diseases: From Environmental Factors to Molecular Opportunities. p 235-249, Springer; Skin Stress Response Pathways. 2016.
  2. Mayumi Ueta: Stevens-Johnson syndrome with ocular complication. biopharmaceutics and drug hypersensitivity. Paul Mossillo & John Pinzini editors, p129-150. Nova Science Publishers, Inc, NY, 2010.
  3. Mayumi Ueta: Ethnic differences in the association of HLA and SJS. European Ophthalmic Review vol3 issue 1, p15-18. Touch Briefings, London, 2009.

Paper

  1. Ueta M.Pathogenesis of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis With Severe Ocular Complications.Front Med (Lausanne). 2021 Nov 17;8:651247.
  2. Ueta M.Findings by an International Collaboration on SJS/TEN With Severe Ocular Complications.Front Med (Lausanne). 2021 Dec 1;8:649661.
  3. Kinoshita S, Ueta M. Editorial: The Updated Understanding of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.Front Med (Lausanne). 2021 Dec 22;8:811570.
  4. Kinoshita F,Yokota I,Mieno H,Ueta M, Bush J,Kinoshita S,Sueki H,Asada H,Morita E,Fukushima M,Sotozono C,Teramukai S. Multi-state model for predicting ocular progression in acute Stevens-Johnson syndrome/toxic epidermal necrolysis.; Japanese Research Committee on Severe Cutaneous Adverse Reaction. PLoS One. 2021 Dec 23;16(12):e0260730.
  5. Ueta M,Nishigaki H,Komai S,Sotozono C,Shigeru K. Difference in the plasma level of miR-628-3p in atopic dermatitis patients with/without atopic keratoconjunctivitis.Immun Inflamm Dis. 2021 Dec;9(4):1815-1819.
  6. Sotozono C,Ueta M,Kinoshita S. Japan: Diagnosis and Management of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis With Severe Ocular Complications. Front. Med., 28 July 2021
  7. Ueta M,Nishigaki H,Mizushima K,Naito Y,Sotozono C,Kinoshita S. Regulation of innate immune response by miR-628-3p upregulated in the plasma of Stevens-Johnson syndrome patients. Ocul Surf. 2021 Jul;21:174-177..
  8. Ueta M,Hosomi K,Park J,Mizuguchi K,Sotozono C,Kinoshita S,Kunisawa J. Categorization of the Ocular Microbiome in Japanese Stevens-Johnson Syndrome Patients With Severe Ocular Complications. Front Cell Infect Microbiol. 2021 Nov 19;11:741654.
  9. Mieno H, Ueta M, Kinoshita F, Teramukai S, Kinoshita S, Sotozono C. Corticosteroid Pulse Therapy for Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Patients with Acute Ocular Involvement. Am J Ophthalmol. 2021 Jun 29:S0002-9394(21)00340-8.
  10. Ueta M, Nishigaki H, Mizushima K, Naito Y, Sotozono C, Kinoshita S. Regulation of innate immune response by miR-628-3p upregulated in the plasma of Stevens-Johnson syndrome patients. Ocul Surf. 2021 Jul;21:174-177.
  11. Komai S, Inatomi T, Nakamura T, Ueta M, Horiguchi G, Teramukai S, Kimura Y, Kagimura T, Fukushima M, Kinoshita S, Sotozono C. Long-term outcome of cultivated oral mucosal epithelial transplantation for fornix reconstruction in chronic cicatrising diseases. Br J Ophthalmol. 2021 May 18:bjophthalmol-2020-318547.
  12. Gervais O, Ueno K, Kawai Y, Hitomi Y, Aiba Y, Ueta M, Nakamura M, Tokunaga K, Nagasaki M. Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population. Eur J Hum Genet. 2021 Aug;29(8):1282-1291.
  13. Wakamatsu TH, Ueta M, Inoue C, Costa KA, Sakano LY, Sallum JM, Gomes JÁ, Kinoshita S. Human Leukocyte Antigen Class I and II Genes Associated with Dipyrone-Related Stevens-Johnson Syndrome and Severe Ocular Complications in a Brazilian Population. Ocul Surf. 2021 Feb 19;20:173-175.
  14. Kawai Y, Hitomi Y, Ueta M, Khor SS, Nakatani K, Sotozono C, Kinoshita S, Nagasaki M, Tokunaga K. Mapping of susceptible variants for cold medicine-related Stevens-Johnson syndrome by whole-genome resequencing. NPJ Genom Med. 2021 Feb 11;6(1):9.
  15. Butt GF, Hassan A, Wallace GR, Kinoshita S, Ahmad S, Ueta M, Rauz S. Human leukocyte antigen B*0702 is protective against ocular Stevens-Johnson syndrome/toxic epidermal necrolysis in the UK population. Sci Rep. 2021 Feb 3;11(1):2928.
  16. Ma KS, Chung WH, Hsueh YJ, Chen SY, Tokunaga K, Kinoshita S, Ma DHK, Ueta M. Human leucocyte antigen association of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications in Han Chinese. Br J Ophthalmol. 2021 Jan 13:bjophthalmol-2020-317105.
  17. Tamagawa-Mineoka R, Ueta M, Arakawa Y, Yasuike R, Nishigaki H, Okuno Y, Hijikuro I, Kinoshita S, Katoh N. Topical application of toll-like receptor 3 inhibitors ameliorates chronic allergic skin inflammation in mice. J Dermatol Sci. 2020 Nov 24:S0923-1811(20)30375-3.
  18. Jongkhajornpong P, Ueta M, Lekhanont K, Puangsricharern V, Prabhasawat P, Chantaren P, Pisuchpen P, Kinoshita S. Association of HLA polymorphisms and acetaminophen-related Steven-Johnson syndrome with severe ocular complications in Thai population. Br J Ophthalmol. 2020 Nov 23:bjophthalmol-2020-317315.
  19. Yoshikawa Y, Ueta M, Nishigaki H, Kinoshita S, Ikeda T, Sotozono C. Predictive biomarkers for the progression of ocular complications in chronic Stevens-Johnson syndrome and toxic Eeidermal necrolysis. Sci Rep. 2020 Nov 3;10(1):18922.
  20. Sotozono C, Inatomi T, Nakamura T, Ueta M, Imai K, Fukuoka H, Komai S, Ishida G, Kitazawa K, Yokoi N, Koizumi N, Kimura Y, Go M, Fukushima M, Kinoshita S. Oral Mucosal Epithelial Transplantation and Limbal-Rigid Contact Lens: A Therapeutic Modality for the Treatment of Severe Ocular Surface Disorders. Cornea. 2020 Nov;39 Suppl 1:S19-S27.
  21. Ueta M, Nishigaki H, Sotozono C, Yokoi N, Mizushima K, Naito Y, Kinoshita S. Regulation of gene expression by miRNA-455-3p, upregulated in the conjunctival epithelium of patients with Stevens-Johnson syndrome in the chronic stage. Sci Rep. 2020 Oct 14;10(1):17239.
  22. Sunaga Y, Kurosawa M, Ochiai H, Watanabe H, Sueki H, Azukizawa H, Asada H, Watanabe Y, Yamaguchi Y, Aihara M, Mizukawa Y, Ohyama M, Hama N, Abe R, Hashizume H, Nakajima S, Nomura T, Kabashima K, Tohyama M, Takahashi H, Mieno H, Ueta M, Sotozono C, Niihara H, Morita E, Kokaze A. The nationwide epidemiological survey of Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan, 2016-2018. J Dermatol Sci. 2020 Dec;100(3):175-182.
  23. Tangamornsuksan W, Chanprasert S, Nadee P, Rungruang S, Meesilsat N, Ueta M, Lohitnavy M. HLA genotypes and cold medicine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis. Sci Rep. 2020 Jun 29;10(1):10589.
  24. Itoi M, Ueta M, Ogino K, Sumi E, Imai K, Teramukai S, Kinoshita S, Sotozono C. Clinical trial to evaluate the therapeutic benefits of limbal-supported contact lens wear for ocular sequelae due to Stevens-Johnson syndrome/toxic epidermal necrolysis. Cont Lens Anterior Eye. 2020 Dec;43(6):535-542.
  25. Chang WC, Abe R, Anderson P, Anderson W, Ardern-Jones MR, Beachkofsky TM, Bellón T, Biala AK, Bouchard C, Cavalleri GL, Chapman N, Chodosh J, Choi HK, Cibotti RR, Divito SJ, Dewar K, Dehaeck U, Etminan M, Forbes D, Fuchs E, Goldman JL, Holmes JH 4th, Hope EA, Hung SI, Hsieh CL, Iovieno A, Jagdeo J, Kim MK, Koelle DM, Lacouture ME, Le Pallec S, Lehloenya RJ, Lim R, Lowe A, McCawley J, McCawley J, Micheletti RG, Mockenhaupt M, Niemeyer K, Norcross MA, Oboh D, Olteanu C, Pasieka HB, Peter J, Pirmohamed M, Rieder M, Saeed HN, Shear NH, Shieh C, Straus S, Sukasem C, Sung C, Trubiano JA, Tsou SY, Ueta M, Volpi S, Wan C, Wang H, Wang ZQ, Weintraub J, Whale C, Wheatley LM, Whyte-Croasdaile S, Williams KB, Wright G, Yeung SN, Zhou L, Chung WH, Phillips EJ, Carleton BC. SJS/TEN 2019: From science to translation. J Dermatol Sci. 2020 Apr;98(1):2-12.
  26. Ueta M. Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications. Expert Rev Clin Immunol. 2020 Mar;16(3):285-291.
  27. Kaneko Y, Seko Y, Sotozono C, Ueta M, Sato S, Shimamoto T, Iwasaku M, Yamada T, Uchino J, Hizawa N, Takayama K. Respiratory complications of Stevens-Johnson syndrome (SJS): 3 cases of SJS-induced obstructive bronchiolitis. Allergol Int. 2020 Feb 14:S1323-8930(20)30009-5.
  28. Yoshikawa Y, Ueta M, Fukuoka H, Inatomi T, Yokota I, Teramukai S, Yokoi N, Kinoshita S, Tajiri K, Ikeda T, Sotozono C. Long-term Progression of Ocular Surface Disease in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Cornea. 2020 Jun;39(6):745-753.
  29. Chantaren P, Jongkhajornpong P, Ueta M, Puangsricharern V, Lekhanont K, Pisuchpen P, Prabhasawat P, Suphapeetiporn K, Kinoshita S. Association of IKZF1 SNPs in cold medicine-related Stevens-Johnson syndrome in Thailand. Clin Transl Allergy. 2019 Nov 22;9:61.
  30. Nakatani K, Ueta M, Khor SS, Hitomi Y, Okudaira Y, Masuya A, Wada Y, Sotozono C, Kinoshita S, Inoko H, Tokunaga K. Identification of HLA-A*02:06:01 as the primary disease susceptibility HLA allele in cold medicine-related Stevens-Johnson syndrome with severe ocular complications by high-resolution NGS-based HLA typing. Sci Rep. 2019 Nov 7;9(1):16240.
  31. Ueta M, Nakamura R, Saito Y, Tokunaga K, Sotozono C, Yabe T, Aihara M, Matsunaga K, Kinoshita S. Association of HLA class I and II gene polymorphisms with acetaminophen-related Stevens-Johnson syndrome with severe ocular complications in Japanese individuals. Hum Genome Var. 2019 Oct 28;6:50.
  32. Ueta M, Sotozono C, Nishigaki H, Ohsako S, Yokoi N, Mizushima K, Naito Y, Kinoshita S. Gene expression analysis of conjunctival epithelium of patients with Stevens-Johnson syndrome in the chronic stage. BMJ Open Ophthalmol. 2019 Jun 16;4(1):e000254.
  33. Shrestha T, Moon HS, Choi W, Yoon HJ, Ji YS, Ueta M, Yoon KC. Characteristics of meibomian gland dysfunction in patients with Stevens-Johnson syndrome. Medicine (Baltimore). 2019 Jun;98(26):e16155.
  34. Nakamura N, Tamagawa-Mineoka R, Ueta M, Konishi E, Yasuike R, Masuda K, Matsunaka H, Murakami Y, Yokosawa E, Katoh N. Stratum corneum Toll-like receptor 3 expressions correlate with the severity of atopic dermatitis lesions. J Dermatol Sci. 2019 J Dermatol Sci. 2019 Jun;94(3):354-357.
  35. Mieno H, Ueta M, Yamada K, Yamanaka Y, Nakayama T, Watanabe A, Kinoshita S, Sotozono C. Expression of prostaglandin E2 receptor 3 in the eyelid epidermis of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.  Br J Ophthalmol. 2020 Jul;104(7):1022-1027.
  36. Jun I, Rim JH, Kim MK, Yoon KC, Joo CK, Kinoshita S, Seo KY, Ueta M. Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population. Br J Ophthalmol. Br J Ophthalmol. 2019 Apr;103(4):573-576.
  37. Ueta M, Hamuro J, Ohsako S, Kinoshita S.Distinctly regulated functions and mobilization of CD11c-positive cells elicited by TLR3- and IPS-1 signaling in the cornea. Immunol Lett. 2019 ;206:49-53.
  38. Ueta M:Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications. Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES183-DES191.
  39. Sotozono C, Ueta M, Yokoi N. Severe Dry Eye With Combined Mechanisms is Involved in the Ocular Sequelae of SJS/TEN at the Chronic Stage. Invest Ophthalmol Vis Sci. 2018 Nov 1;59(14):DES80-DES86.
  40. Su SC, Chen CB, Chang WC, Wang CW, Fan WL, Lu LY, Nakamura R, Saito Y, Ueta M, Kinoshita S, Sukasem C, Yampayon K, Kijsanayotin P, Nakkam N, Saksit N, Tassaneeyakul W, Aihara M, Lin YJ, Chang CJ, Wu T, Hung SI, Chung WH. HLA Alleles and CYP2C9*3 as Predictors of Phenytoin Hypersensitivity in East Asians. Clin Pharmacol Ther. 2019 Feb;105(2):476-485.
  41. Miyazaki D, Shimizu D, Shimizu Y, Inoue Y, Inoue T, Higaki S, Ueta M, Sugita S; Real-time PCR for ocular cytomegalovirus infection study group. Diagnostic efficacy of real-time PCR for ocular cytomegalovirus infections. Graefes Arch Clin Exp Ophthalmol. 2018 Dec;256(12):2413-2420.
  42. Jongkhajornpong P, Lekhanont K, Pisuchpen P, Chantaren P, Puangsricharern V, Prabhasawat P, Suphapeetiporn K, Kinoshita S, Ueta M. Association between HLA-B*44:03-HLA-C*07:01 haplotype and cold medicine-related Stevens-Johnson syndrome with severe ocular complications in Thailand. Br J Ophthalmol. 2018 Sep;102(9):1303-1307.
  43. Tamagawa-Mineoka R, Yasuoka N, Ueta M, Katoh N. Influence of topical steroids on intraocular pressure in patients with atopic dermatitis. Allergol Int. 2018 Jul;67(3):388-391.
  44. Shinomiya K, Ueta M, Kinoshita S. A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision. Sci Rep. 2018 Jan 24;8(1):1483.
  45. Ueta M, Nishigaki H, Sotozono C, Kinoshita S. Downregulation of interferon-γ-induced protein 10 in the tears of patients with Stevens-Johnson syndrome with severe ocular complications in the chronic stage. BMJ Open Ophthalmol. 2017 Aug 7;1(1):e000073.
  46. Yoon HJ, Kim MK, Seo KY, Ueta M, Yoon KC. Effectiveness of photodynamic therapy with verteporfin combined with intrastromal bev cizumab for corneal neovascularization in Stevens-Johnson syndrome. Int Ophthalmol. 2019 Jan;39(1):55-62.
  47. Kannabiran C, Ueta M, Sangwan V, Rathi V, Basu S, Tokunaga K, Kinoshita S. Association of Human Leukocyte Antigen Class 1 genes with Stevens Johnson Syndrome with severe ocular complications in an Indian population. Sci Rep. 2017 Nov 21;7(1):15960.
  48. Lee HK, Yoon KC, Seo KY, Ueta M, Kim MK. Chronic ocular complications of Stevens-Johnson syndrome associated with causative medications in Korea. J Allergy Clin Immunol Pract. 2018 Mar - Apr;6(2):700-702.e2. (2016 IF=5.317)
  49. Ueta M, Hamuro J, Nishigaki H, Nakamura N, Shinomiya K, Mizushima K, Hitomi Y, Tamagawa-Mineoka R, Yokoi N, Naito Y, Tokunaga K, Katoh N, Sotozono C, Kinoshita S. Mucocutaneous Inflammation in the Ikaros Family Zinc Finger 1 (IKZF1) - keratin 5 specifc transgenic mice. Allergy. 2018 Feb;73(2):395-404
  50. Yasuike R, Tamagawa-Mineoka R, Ueta M, Nakamura N, Kinoshita S, Katoh N. The role of toll-like receptor 3 in chronic contact hypersensitivity induced by repeated elicitation. J Dermatol Sci. 2017 Nov;88(2):184-191.
  51. Okada Y, Ueta M. Data Sparsity in Study on Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications-Reply. JAMA Ophthalmol. 2017 Aug 1;135(8):894-895 (2016 IF=5.625)
  52. Wakamatsu TH, Ueta M, Tokunaga K, Okada Y, Loureiro RR, Costa KA, Sallum JM, Milhomens JA, Inoue C, Sotozono C, Gomes JÁ, Kinoshita S. Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Population. JAMA Ophthalmol. 2017 Apr 1;135(4):355-360. (2016 IF=5.625)
  53. Ueta M,Sawai H,Shingaki R, Kawai Y, Sotozono C,Kojima K, Yoon KC,Kim MK,Seo KY,Joo CK,Nagasaki M, Kinoshita S,Tokunaga K. Genome-wide association study using the ethnicity-specific Japonica array: Identification of new susceptibility loci for cold medicine-related Stevens-Johnson syndrome with severe ocular complications. J Human Genetics. 2017 Apr;62(4):485-489. (2016 IF=2.471)
  54. Saito K, Ueta M, Maekawa K, Sotozono C, Kinoshita S, Saito Y. Plasma Lipid Profiling of Patients with Chronic Ocular Complications Caused by Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis. PLoS One. 2016 Nov 29;11(11):e0167402. (2016 IF=2.806)
  55. Jain R, Sharma N, Basu S, Iyer G, Ueta M, Sotozono C, Kannibiran C, Rathi VM, Gupta N, Kinoshita S, Gomes JA, Chodosh J, Sangwan VS. Reply: Amniotic membrane transplantation in Stevens-Johnson Syndrome. Surv Ophthalmol. Surv Ophthalmol. 2017 Mar - Apr;62(2):249-250. (2016 IF=3.374)
  56. Koizumi N,Miyazaki D,Inoue T,Ohtani F,Kandori-Inoue M,Inatomi T,Sotozono C,Nakagawa H,Horikiri T,Ueta M,Nakamura T,Inoue Y,Ohashi Y,Kinoshita S. The effect of topical application of 0.15% ganciclovir gel on cytomegalovirus corneal endotheliitis. Br J Ophthalmol. 2017 Feb;101(2):114-119. (2016 IF=3.806)
  57. Kojima S,Inoue T,Kikuta J,Furuya M,Koga A,Fujimoto T,Ueta M,Kinoshita S, Ishii M,Tanihara H.Visualization of Intravital Immune Cell Dynamics After Conjunctival Surgery Using Multiphoton Microscopy. Invest Ophthalmol Vis Sci. 2016 Mar 1;57(3):1207-12. (2016 IF=3.303)
  58. Kohanim S,Palioura S,Saeed HN,Akpek EK,Amescua G,Basu S,Blomquist PH,Bouchard CS,Dart JK,Gai X,Gomes JA,Gregory DG,Iyer G,Jacobs DS,Johnson AJ,Kinoshita S,Mantagos IS,Mehta JS,Perez VL,Pflugfelder SC,Sangwan VS,Sippel KC,Sotozono C,Srinivasan B,Tan DT,Tandon R,Tseng SC,Ueta M,Chodosh J. Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease. Ocul Surf. 2016 Apr;14(2):168-88. (2016 IF=4.383)
  59. Jain R,Sharma N,Basu S,Iyer G,Ueta M,Sotozono C,Kannibiran C,Rathi VM,Gupta N,Kinoshita S,Gomes JA,Chodosh J,Sangwan VS. Stevens Johnsons Syndrome: The Role of an Ophthalmologist. Surv Ophthalmol. 2016 Jul-Aug;61(4):369-99. (2016 IF=3.374)
  60. Lee HS,Ueta M,Kim MK,Seo KY,Sotozono C,Kinoshita S,Yoon KC. Analysis of Ocular Manifestation and Genetic Association of Allopurinol-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in South Korea. Cornea. 2016 Feb; 35(2) :199-204. (2016 IF=1.833)
  61. Ueta M,Koga A,Kikuta J,Yamada K,Kojima S,Shinomiya K,Ishii M,Kinoshita S. Intravital imaging of the cellular dynamics of LysM-positive cells in a murine corneal suture model. Br J Ophthalmol. 2016 Mar;100(3):432-5. (2016 IF=3.806)
  62. Kohanim S,Palioura S,Saeed HN,Akpek EK,Amescua G,Basu S,Blomquist PH,Bouchard CS,Dart JK,Gai X,Gomes JA,Gregory DG,Iyer G,Jacobs DS,Johnson AJ,Kinoshita S,Mantagos IS,Mehta JS,Perez VL,Pflugfelder SC,Sangwan VS,Sippel KC,Sotozono C,Srinivasan B,Tan DT,Tandon R,Tseng SC,Ueta M,Chodosh J. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. I. Systemic Disease.Ocul Surf. 2016 Jan;14(1):2-19. Review. (2016 IF=4.383)
  63. Jongkhajornpong P,Lekhanont K,Ueta M,Kitazawa K,Kawasaki S, Kinoshita S. Novel TACSTD2 mutation in gelatinous drop-like corneal dystrophy. Human Genome Variation 2, 2015 Nov 26;2:15047.
  64. Ueta M,Tokunaga K, Sotozono C,Sawai H,Yoon KC,Kim MK,Seo KY,Joo CK,Tashiro K, Kinoshita S. HLA-A*02:06 and PTGER3 polymorphism exert additive effects in cold medicine-related Stevens–Johnson syndrome with severe ocular complications. Human Genome Variation 2,2015 Jul 16;2:15023.
  65. Maekawa K,Nakamura R,Kaniwa N,Mizusawa S,Kitamoto A,Kitamoto T,Ukaji M, Matsuzawa Y,Sugiyama E,Uchida Y,Kurose K,Ueta M,Sotozono C,Ikeda H,Yagami A,Matsukura S,Kinoshita S,Muramatsu M,Ikezawa Z, Sekine A,Furuya H,Takahashi Y,Matsunaga K,Aihara M,Saito Y; Japan Pharmacogenomics Data Science Consortium. Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese. Pharmacogenomics. 2015 Oct;16(15):1689-99. (2015 IF=3.218)
  66. Ueta M. Genetic Predisposition to Stevens-Johnson Syndrome With Severe Ocular Surface Complications. Cornea. 2015 Nov;34 Suppl 11:S158-65. (2015 IF=2.042)
  67. Kaniwa N,Ueta M,Nakamura R,Okamoto-Uchida Y,Sugiyama E,Maekawa K, Takahashi Y,Furuya H,Yagami A,Matsukura S,Ikezawa Z,Matsunaga K, Sotozono C,Aihara M,Kinoshita S,Saito Y. Drugs causing severe ocular surface involvements in Japanese patients with Stevens-Johnson syndrome/toxic epidermal necrolysis. Allergol Int. 2015 Oct;64(4):379-81. (2015 IF=2.457)
  68. Sotozono C,Ueta M,Nakatani E,Kitami A,Watanabe H,Sueki H,Iijima M, Aihara M, Ikezawa Z,Aihara Y, Kano Y,Shiohara T,Tohyama M, Shirakata Y, Kaneda H, Fukushima M, Kinoshita S, Hashimoto K. Predictive Factors associated with Acute Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Am J Ophthalmol. 2015 Aug;160(2):228-237.e2.(2015 IF=3.871)
  69. Ueta M,Sawai H,Sotozono C,Hitomi Y,Kaniwa N,Kim MK,Seo KY,Yoon KC,Joo CK,Kannabiran C,Wakamatsu TH,Sangwan V,Rathi V,Basu S,Ozeki T, Mushiroda T,Sugiyama E,Maekawa K,Nakamura R,Aihara M, Matsunaga K, Sekine A,Gomes JAP,Hamuro J,Saito Y,Kubo M,Kinoshita S, Tokunaga K. New Susceptibility Gene, IKZF1, for cold medicine–related Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis with Severe Mucosal Involvements. J Allergy Clin Immunol. 2015 Jun;135(6):1538-1545.e17. (2015 IF=11.476)
  70. Ueta M, Shoji J, Sotozono C, Kinoshita K. Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. Clinical and Translational Allergy, 2014 Oct 30;4:40.
  71. Nakamura N, Tamagawa-Mineoka R, Ueta M, Kinoshita S, Katoh N. Toll-Like Receptor 3 Increases Allergic and Irritant Contact Dermatitis. J Invest Dermatol. 2015 Feb;135(2):411-7.
  72. Kim DH, Yoon KC, Seo KY, Lee HS, Yoon SC, Sotozono C, Ueta M, Kim MK. The Role of Systemic Immunomodulatory Treatment and Prognostic Factors on Chronic Ocular Complications in Stevens-Johnson Syndrome. Ophthalmology. 2015 Feb;122(2):254-64..
  73. Ueta M, Kannabiran C, Wakamatsu TH, Kim MK,Yoon KC, Seo KY, Joo CK, Sangwan V, Rathi V, Basu S, Shamaila A, Lee HS, Yoon S, Sotozono C, Gomes JAP, Tokunaga K, Kinoshita S. Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications. Sci Rep. 2014 ;4:5981.
  74. Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Kaneda H, Fukushima M, Kinoshita S. Cultivated oral mucosal epithelial transplantation for persistent epithelial defect in severe ocular surface diseases with acute inflammatory activity. Acta Ophthalmol. 2014 ; 92(6):e447-53.
  75. Yamada K,Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S. Upregulation of Toll-like receptor 5 expression in the conjunctival epithelium of various human ocular surface diseases. Br J Ophthalmol. 2014 ;. 98(8):1116-9.
  76. Ueta M, Kaniwa N, Sotozono C, Tokunaga K, Saito Y, Sawai H, Miyadera H, Sugiyama E, Maekawa K, Nakamura R, Nagato M, Aihara M, Matsunaga K, Takahashi Y, Furuya H, Muramatsu M, Ikezawa Z, Kinoshita S.Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement. Sci Rep. 2014;4:4862.
  77. Ueta M, Sotozono C, Koga A, Yokoi N, Kinoshita S. Usefulness of a New Therapy Using Rebamipide Eyedrops in Patients with VKC/AKC Refractory to Conventional Anti-Allergic Treatments. Allergol Int. 2014 63:75-81
  78. Isogai H, Miyadera H, Ueta M, Sotozono C, Kinoshita S, Tokunaga K, Hirayama N. In Silico Risk Assessment of HLA-A*02:06-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Caused by Cold Medicine Ingredients. J Toxicol. 2013;2013:514068.
  79. Kaniwa N, Sugiyama E, Saito Y, Kurose K, Maekawa K, Hasegawa R, Furuya H, Ikeda H, Takahashi Y, Muramatsu M, Tohkin M, Ozeki T, Mushiroda T, Kubo M, Kamatani N, Abe M, Yagami A, Ueta M, Sotozono C, Kinoshita S, Ikezawa Z, Matsunaga K, Aihara M. Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects. Pharmacogenomics. 2013. 14:1821-31
  80. Ueta M, Mizushima K, Naito Y, Narumiya S, Shinomiya K,1 Kinoshita S. Suppression of polyI:C-inducible gene expression by EP3 in murine conjunctival epithelium. Immunol Lett. 2013 Sep 12. pii: S0165-2478(13)00121-1.
  81. Watanabe A, Sotozono C, Ueta M, Katsuhiko Shinomiya, Kinoshita S, Kakizaki H, Selva D, FRANZCO F. Folliculitis in Clinically “Quiet” Chronic Stevens-Johnson syndrome. Ophthal Plast Reconstr Surg. 2014, 30:80-2.
  82. Ueta M, Sotozono C, Yokoi N, Kinoshita S: Rebamipide Suppresses PolyI:C-Stimulated Cytokine Production in Human Conjunctival Epithelial Cells. J Ocul Pharmacol Ther. 2013 Sep;29(7):688-93.
  83. Shinomiya K, Ueta M, Sotozono C, Inatomi T, Yokoi N, Koizumi N, Kinoshita S: Immunohistochemical analysis of inflammatory limbal conjunctiva adjacent to Mooren's ulcer. Br J Ophthalmol. 2013; 97(3):362-6
  84. Sotozono C, Inatomi T, Nakamura T, Koizumi N, Yokoi N, Ueta M, Matsuyama K, Miyakoda K, Kaneda H, Fukushima M, Kinoshita S: Visual Improvement after Cultivated Oral Mucosal Epithelial Transplantation. Ophthalmology. 2013; 120(1): 193-200.
  85. Ueta M: Epistatic interactions associated with stevens-johnson syndrome. Cornea. 2012; Suppl 1:S57-62
  86. Ueta M, Sotozono C, Yamada K, Yokoi N, Inatomi T, Kinoshita S: Expression of prostaglandin E receptor subtype EP4 in conjunctival epithelium of patients with ocular surface disorders: case-control study. BMJ Open. 2012; 2(5): pii: e001330.
  87. Ueta M, Tokunaga K, Sotozono C, Sawai H, Tamiya G, Inatomi T, Kinoshita S: HLA-A*0206 with TLR3 Polymorphisms Exerts More than Additive Effects in Stevens-Johnson Syndrome with Severe Ocular Surface Complications. PLoS One. 2012; 7(8):e43650.
  88. Ueta M, Kinoshita S: Ocular surface inflammation is regulated by innate immunity. Prog Retin Eye Res. 2012; 31(6): 551-575.
  89. Imai K, Ueta M, Mori K, Ueno M, Ikeda Y, Oga T, Yokoi N, Shinomiya K, Narumiya S, Kinoshita S: Expression of prostaglandin F receptor in scleral and subconjunctival tissue. Br J Ophthalmol. 2012; 96(8): 1148-1149.
  90. Ueta M, Matsuoka T, Sotozono C, Kinoshita S: Prostaglandin E2 Suppresses Poly I: C-Stimulated Cytokine Production Via EP2 and EP3 in Immortalized Human Corneal Epithelial Cells. Cornea. 2012; 31(11): 1294-1298.
  91. Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S: Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes. J Allergy Clin Immunol. 2012; 129(5): 1413-1416.e11.
  92. Ueta M, Sotozono C, Yokoi N, Kinoshita S: Downregulation of monocyte chemoattractant protein 1 expression by prostaglandin e2 in human ocular surface epithelium. Arch Ophthalmol. 2012; 130(2): 249-251.
  93. Ueta M, Yokoi N, Kinoshita S: Endothelin-1 production upon polyI:C stimulation of human conjunctival epithelium. Br J Ophthalmol. 2011; 95(12):1760-1761.
  94. Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S: Prostaglandin E Receptor Subtype EP3 Expression in Human Conjunctival Epithelium and Its Changes in Various Ocular Surface Disorders. PLoS One. 2011; 6(9): e25209.
  95. Tohkin M, Kaniwa N, Saito Y, Sugiyama E, Kurose K, Nishikawa J, Hasegawa R, Aihara M, Matsunaga K, Abe M, Furuya H, Takahashi Y, Ikeda H, Muramatsu M, Ueta M, Sotozono C, Kinoshita S, Ikezawa Z: A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Pharmacogenomics J. 2013 ;13(1):60-9.
  96. Ueta M, Sotozono C, Kinoshita S: Expression of interleukin-4 receptor α in human corneal epithelial cells. Jpn J Ophthalmol. 2011; 55(4): 405-410.
  97. Yagi T, Sotozono C, Tanaka M, Fuwa M, Sekiyama E, Ueta M, Tashiro K, Kinoshita S: Cytokine storm arising on the ocular surface in a patient with Stevens-Johnson syndrome. Br J Ophthalmol. 2011; 95(7): 1030-1031.
  98. Ueta M, Matsuoka T, Yokoi N, Kinoshita S: Prostaglandin E2 suppresses polyinosine-polycytidylic acid (polyI:C)-stimulated cytokine production via prostaglandin (EP) 2 and 3 in human conjunctival epithelial cells. Br J Ophthalmol. 2011; 95(6): 859-863.
  99. Ueta M, Matsuoka T, Yokoi N, Kinoshita S: Prostaglandin E receptor subtype EP3 downregulates TSLP expression in human conjunctival epithelium. Br J Ophthalmol. 2011; 95(5): 742-743.
  100. Ueta M, Kawai T, Yokoi N, Akira S, Kinoshita S: Contribution of IPS-1 to polyI:C-induced cytokine production in conjunctival epithelial cells. Biochem Biophys Res Commun. 2011; 404(1): 419-423.
  101. Kaniwa N, Saito Y, Aihara M, Matsunaga K, Tohkin M, Kurose K, Furuya H, Takahashi Y, Muramatsu M, Kinoshita S, Abe M, Ikeda H, Kashiwagi M, Song Y, Ueta M, Sotozono C, Ikezawa Z, Hasegawa R: JSAR research group. HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Epilepsia. 2010; 51(12): 2461-2465.
  102. Ueta M: Regulation of ocular surface inflammation by prostaglandin E receptor subtype EP3. Cornea. 2010; 29(11): S57-61.
  103. Ueta M, Sotozono C, Nakano M, Taniguchi T, Yagi T, Tokuda Y, Fuwa M, Inatomi T, Yokoi N, Tashiro K, Kinoshita S: Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study. J Allergy Clin Immunol. 2010; 126(6): 1218-1225.
  104. Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S: Prostaglandin E receptor 4 expression in human conjunctival epithelium and its downregulation in devastating ocular surface inflammatory disorders. Arch Ophthalmol. 2010; 128(10): 1369-1371.
  105. Ueta M, Hamuro J, Kinoshita S: Spatio-temporal dual effects of IκBζ dictates the caution on visual disturbance resulting from IκBζ deficiency. Immunol Lett. 2010; 133(2): 115.
  106. Ueta M, Kinoshita S: Ocular surface inflammation mediated by innate immunity. Eye Contact Lens. 2010; 36(5): 269-281.
  107. Ueta M, Mizushima K, Yokoi N, Naito Y, Kinoshita S: Gene-expression analysis of polyI:C-stimulated primary human conjunctival epithelial cells. Br J Ophthalmol. 2010; 94(11): 1528-1532.
  108. Ueta M, Mizushima K, Yokoi N, Naito Y, Kinoshita S: Expression of the interleukin-4 receptor alpha in human conjunctival epithelial cells. Br J Ophthalmol. 2010; 94(9): 1239-1243.
  109. Kinoshita S, Ueta M: Innate immunity of the ocular surface. Jpn J Ophthalmol. 2010; 54(3): 194-198.
  110. Sotozono C, Ueta M, Kinoshita S: Systemic and local management at the onset of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications. Am J Ophthalmol, 2010; 149(2): 354.
  111. Ueta M, Kinoshita S: Innate immunity of the ocular surface. Brain Res Bull. 2010; 81(2-3): 219-228.
  112. Sotozono C, Ueta M, Kinoshita S: The management of severe ocular complications of stevens-johnson syndrome and toxic epidermal necrolysis. Arch Dermatol, 2009; 145(11): 1336-1337.
  113. Honda T, Matsuoka T, Ueta M, Kabashima K, Miyachi Y, Narumiya S: Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity. J Allergy Clin Immunol. 2009; 124(4): 809-818.
  114. Ueta M, Uematsu S, Akira S, Kinoshita S: Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis. J Allergy Clin Immunol. 2009; 123(5): 1187-1189.
  115. Ueta M, Matsushita M, Sotozono C, Kinoshita S, Tokunaga K: Identification of a novel HLA-B allele, HLA-B*5904. Tissue Antigens. 2009; 73(6): 612-614.
  116. Ueta M, Sotozono C, Takahashi J, Kojima K, Kinoshita S: Examination of Staphylococcus aureus on the ocular surface of patients with catarrhal ulcers. Cornea. 2009; 28(7): 780-782.
  117. Araki Y, Sotozono C, Inatomi T, Ueta M, Yokoi N, Ueda E, Kishimoto S, Kinoshita S: Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset. Am J Ophthalmol. 2009; 147(6): 1004-1011.
  118. Sotozono C, Ueta M, Koizumi N, Inatomi T, Shirakata Y, Ikezawa Z, Hashimoto K, Kinoshita S: Diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis with ocular complications. Ophthalmology. 2009; 116(4): 685-690.
  119. Ueta M, Matsuoka T, Narumiya S, Kinoshita S: Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis. J Allergy Clin Immunol. 2009; 123(2): 466-471.
  120. Kaniwa N, Saito Y, Aihara M, Matsunaga K, Tohkin M, Kurose K, Sawada J, Furuya H, Takahashi Y, Muramatsu M, Kinoshita S, Abe M, Ikeda H, Kashiwagi M, Song Y, Ueta M, Sotozono C, Ikezawa Z, Hasegawa R: JSAR research group. HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis. Pharmacogenomics. 2008; 9(11): 1617-1622.
  121. Ueta M: Innate immunity of the ocular surface and ocular surface inflammatory disorders. Cornea. 2008; 27(Suppl 1):S31-40.
  122. Ueta M, Sotozono C, Inatomi T, Kojima K, Hamuro J, Kinoshita S: Association of Fas Ligand gene polymorphism with Stevens-Johnson syndrome. Br J Ophthalmol. 2008; 92(7): 989-991.
  123. Ueta M, Hamuro J, Ueda E, Katoh N, Yamamoto M, Takeda K, Akira S, Kinoshita S: Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice. Invest Ophthalmol Vis Sci. 2008; 49(8): 3387-3394.
  124. Ueta M, Tokunaga K, Sotozono C, Inatomi T, Yabe T, Matsushita M, Mitsuishi Y, Kinoshita S: HLA class I and II gene polymorphisms in Stevens-Johnson syndrome with ocular complications in Japanese. Mol Vis. 2008; 14: 550-555.
  125. Ueta M, Sotozono C, Inatomi T, Kojima K, Hamuro J, Kinoshita S: Association of combined IL-13/IL-4R signaling pathway gene polymorphism with Stevens-Johnson syndrome accompanied by ocular surface complications. Invest Ophthalmol Vis Sci. 2008; 49(5): 1809-1813.
  126. Kojima K, Ueta M, Hamuro J, Hozono Y, Kawasaki S, Yokoi N, Kinoshita S: Human conjunctival epithelial cells express functional Toll-like receptor 5. Br J Ophthalmol. 2008; 92(3): 411-416.
  127. Ueta M, Sotozono C, Inatomi T, Kojima K, Hamuro J, Kinoshita S: Association of IL4R polymorphisms with Stevens-Johnson syndrome. J Allergy Clin Immunol. 2007; 120(6): 1457-1459.
  128. Ueta M, Nakamura T, Tanaka S, Kojima K, Kinoshita S: Development of eosinophilic conjunctival inflammation at late-phase reaction in mast cell-deficient mice. J Allergy Clin Immunol. 2007; 120(2): 476-478.
  129. Ueta M, Sotozono C, Inatomi T, Kojima K, Tashiro K, Hamuro J, Kinoshita S: Toll like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome. Br J Ophthalmol.  2007; 91(7): 962-965.
  130. Sotozono C, Ang LP, Koizumi N, Higashihara H, Ueta M, Inatomi T, Yokoi N, Kaido M, Dogru M, Shimazaki J, Tsubota K, Yamada M, Kinoshita S: New grading system for the evaluation of chronic ocular manifestations in patients with Stevens-Johnson syndrome. Opthalmology. 2007; 114(7): 1294-1302.
  131. Ueta M, Sotozono C, Tokunaga K, Yabe T, Kinoshita S: Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese. Am J Ophthalmol. 2007; 143(2): 367-368.
  132. Ueta M, Iida T, Sakamoto M, Sotozono C, Takahashi J, Kojima K, Okada K, Chen X, Kinoshita S, Honda T: Polyclonality of Staphylococcus epidermidis residing on the healthy ocular surface. J Med Microbiol. 2007; 56(Pt 1): 77-82.
  133. Hozono Y, Ueta M, Hamuro J, Kojima K, Kawasaki S, Yamazaki K, Kinoshita S: Human corneal epithelial cells respond to ocular-pathogenic, but not to nonpathogenic-flagellin. Biochem Biophys Res Commun 2006; 347(1): 238-247.
  134. Naito Y, Takagi T, Mizushima K, Ueta M, Kinoshita S, Handa O, Kokura S, Ichikawa H, Yoshida N, Yoshikawa T: Gene expression clusters of a lipopolysaccharide-stimulated pathway in peripheral blood monocytes of Japanese patients with Crohn's disease. Aliment Pharmacol Ther. 2006; 24(Suppl 4): 256-265.
  135. Ono T, Park KS, Ueta M, Iida T, Honda T: Identification of proteins secreted via Vibrio parahaemolyticus type III secretion system 1.Infect Immun. 2006; 74(2): 1032-1042.
  136. Ueta M, Hamuro J, Kiyono H, Kinoshita S: Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005; 331(1): 285-294.
  137. Ueta M, Hamuro J, Yamamoto M, Kaseda K, Akira S, Kinoshita S: Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta gene-disrupted mice. Invest Ophthalmol Vis Sci. 2005; 46(2): 579-588.
  138. Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, Kiyono H: Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J Immunol. 2004; 173(5): 3337-3347.
  139. Ueta M, Kweon MN, Sano Y, Sotozono C, Yamada J, Koizumi N, Kiyono H, Kinoshita S: Immunosuppressive properties of human amniotic membrane for mixed lymphocyte reaction. Clin Exp Immunol, 2002; 129(3): 464-470.

International Conference

Invited:

  1. 5th Chulalongkorn Eye Center-Kyoto Prefectural University of Medicine Joint meeting.Chulalongkorn University, Bangkok, Thailand, 2019.10.31.
    Ueta M,IKZF1, a susceptibility Gene for cold medicine related Stevens-Johnson syndrome / Toxic Epidermal Necrolysis with severe ocular complications
  2. SJS/TEN 2019
    Ueta M, Immunogenomics of SJS/TEN Eye Disease, SJS/TEN 2019: From Science to Translation, Vancuvar, Canada, symposium, SESSION 6(Update in Ocular Science), 2-3, April 26th, 2019.
  3. 2019 OSW (Ocular Surface Workshop)
    Ueta M,Genetic Predisposition and Pathology of SJS with severe ocular complications, 2019 OSW (Ocular Surface Workshop), introduction to SJS, Karnal, India, 2.Feb.2019, symposium
  4. 2019 OSW (Ocular Surface Workshop)
    Ueta M,Genetic Predisposition and Pathology of SJS with severe ocular complications, 2019 OSW (Ocular Surface Workshop), OCP, Karnal, India, 3.Feb.2019, symposium
  5. 2018 ISCAR (international severe cutaneous adverse reaction) meeting, Matsue, Japan, 11.10.2018.
    Ueta M,Genetic Predisposition and Pathology of Stevens-Johnson Syndrome with Severe Ocular Complications
  6. 4nd Chulalongkorn Eye Center-Kyoto Prefectural University of Medicine Joint meeting.Chulalongkorn University, Bangkok, Thailand, 2018.8.31.
    Ueta M,Genetic background of Stevens-Johnson syndrome with ocular complications
  7. Ocular Surface and Keratoprosthesis Conference (OSKON) 2018, Chennai, India, 2018.7.27.
    Ueta M, Genetics and Stevens-Johnson Syndrome (SJS) - How close are we to identifying predisposed individuals?
  8. Gordon Research Conference 2018: Cornea and Ocular Surface Biology and Pathology.Defining the Mechanisms Through Which the Cornea, Tear Film and Immune System Operate Under Pathological Conditions, Session: Innate and Acquired Immunity in Corneal Pathophysiology, Ventura, CA, US.February 18 - 23, 2018.
    Ueta M, Regulation of CD11c positive cells by TLR3 in the cornea.Feb 21, 2018.
  9. 3nd Chulalongkorn Eye Center-Kyoto Prefectural University of Medicine Joint meeting.Chulalongkorn University, Bangkok, Thailand, 2017.8.22.
    Ueta M, Pathology of Stevens-Johnson Syndrome.
  10. SJS/TEN 2017, Orland USA March 2nd, 2017.
    Ueta M, Katsushi Tokunaga, Hiromi Sawai, Chie Sotozono, Shigeru KinoshitaGenetic Predispositions for Cold medicine related Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis with Severe Ocular Complications
  11. I PANCORNEA CONGRESS February 24, 2017 in Miami, USA, 2017.2.24.
    Ueta M,HLA and Stevens Johnson Syndrome, SESSION 2 Shut Up, Inflammation
  12. 2nd Chulalongkorn Eye Center-Kyoto Prefectural University of Medicine Joint meeting.Chulalongkorn University, Bangkok, Thailand, 2016.8.23.
    Ueta M, Pathology of Stevens-Johnson Syndrome.
  13. The 56th Annual meeting of the Ophthalmological Society of Taiwan.Taipei, Taiwan, 2015.11.29.
    Ueta M, Genetic predisposition of Cold medicine-Related Stevens-Johnson Syndrome with Ocular Surface Complications.Symposium.
  14. Chulalongkorn Eye Center-Kyoto Prefectural University of Medicine Joint meeting.Chulalongkorn University, Bangkok, Thailand, 2015.8.18.
    Ueta M, Genetic predisposition of Stevens-Johnson Syndrome with Severe Ocular Complications.
  15. OSKON2015, Chennai, India, 2015.7.10.
    Ueta M, Genetic predisposition and Immunopathogenesis of Stevens-Johnson Syndrome (SJS) with severe ocular complications - How much do we understand the disease?
  16. OSKON2015, Chennai, India, 2015.7.10.
    Ueta M, Anti-inflammatory effect of Rebamipide eye drops
  17. Ueta M, Clinical finding of Stevens-Johnson Syndrome with severe ocular complications. 38 SIMASP, SaoPaulo, Brazil, 2015.3.5
  18. Ueta M, Suppressive effects of IL-8, ECP and total IgE in the tear of atopic keratoconjunctivitis by rebamipide eye drops. 38 SIMASP, SaoPaulo, Brazil, 2015.3.5
  19. Ueta M, Tokunaga K, Sotozono C, Sawai H, Kinoshita K. HLA-A*0206 with TLR3 Polymorphism Exerts more than Additive Effects in Cold medicine related Stevens-Johnson Syndrome with Severe Ocular Complications. 2014 ISER (The International Society for Eye Research) XXI Biennial Meeting, San Francisco, CA, USA, July 21, 2014
  20. Ueta M: Ocular Surface Inflammation and Ocular Surface Epithelial Cells. Biology & Pathobiology of the Cornea, Gordon Conference, Ventura, CA, USA, February 19, 2014
  21. Ueta M: Genetic Predisposition of Stevens-Johnson Syndrome with Ocular Complications. APAO/SOE Busan 2012, Busan, Korea, 2012.4.16.
  22. Ueta M: Earlier is Better for the Treatment of Stevens-Johnson Syndrom. APAO/SOE Busan 2012 , Busan, Korea, 2012.4.13.
  23. Ueta M: Regulation of Ocular Surface Inflammation by Prostaglandin E Receptor Subtype EP3. ESF-JSPS Frontier Science Conference for Young Researchers Cutting Edge Immunology and its Clinical Application(日本欧州先端科学セミナー), Hulshort, Netherlands, 2011.3.5.
  24. Ueta M: The importance of commensal bacteria on the ocular surface. APAO Sydney 2011 Congress, Sydney, Australia, 2011. 3. 22.
  25. Ueta M: Innate Immunity of the Ocular Surface. The 2nd Asia Cornea Society Biennial Scientific Meeting. Symposium 5. Basic Research (1) Angiogenesis and Immunoregulation, Kyoto, JAPAN, 2010.12.1.
  26. Ueta M: Downregulation of TSLP expression by Prostaglandin E Receptor Subtype EP3 in human conjunctival epithelium. 2010 Korea-Japan Joint Allergy Symposium and KAAACI (the Korean Academy & Asthma, Allergy and Clinical Immunology) Spring Congress, Soul, Korea, 2010. 5. 28.

General:

  1. SJS/TEN 2021: Collaboration, Innovation and Community August 28, 2021
    Ueta M, Regulation of innate immune response by miR-628-3p upregulated in the plasma of SJS/TEN with severe ocular complications (SOC)
  2. ESCRS (European Society of Cataract & Refractive Surgery) 2020 winter 2020.2.21-23, Marrakech, Morocco
    Mayumi Ueta, Ryosuke Nakamura, Yoshiro Saito, Katsushi Tokunaga, Chie Sotozono, Toshio Yabe, Michiko Aihara, Kayoko Matsunaga, Shigeru Kinoshita. HLA association with Acetaminophen-related Stevens-Johnson syndrome with severe ocular complications in Japanese. poster
  3. World Allergy Congress 2019,Lyon, France,2019.12.12
    Ueta M,Nishigaki H,Sotozono C,Yokoi N,Kinoshita S.Comprehensive miRNA analysis of conjunctival epithelium of Stevens-Johnson syndrome patients in the chronic stage.
  4. 2019 American Academy of Ophthalmology, San Francisco, USA, October 12 - 15, 2019.
    Matsumoto K,Fukuoka H,Ueta M,Inatomi T,Yokoi N,Kinoshita S,Sotozono C.Indications and Complications of Therapeutic SCL Use. Mieno H,Ueta M,Kinoshita S,Sotozono C.Prognosis of Corticosteroid Pulse Therapy and Early Ophthalmological Intervention for Ocular Disorder in SJS/TEN Cases. Kinoshita S,Chantaren P,Jongkhajornpong P,Puangsricharern V,Lekhanont K,Pisuchpen P,Ueta M.Association of IKZF1 SNPs in Cold Medicine?Related SJS with Severe Ocular Complications. Ueta M.Patchima Chantaren, Passara Jongkhajornpong, Vilavun Puangsricharern, Kaevalin Lekhanont, Phattrawan Pisuchpen, Pinnita Prabhasawat, Kanya Suphapeetiporn.
  5. European Human Genetics Conference Gothenburg, Sweden, June 15-18, 2019.
    Yosuke Kawai, Yuki Hitomi, Mayumi Ueta, Seik-Soon Khor, Ken Nakatani, Chie Sotozono, Shigeru Kinoshita, Masao Nagasaki, Katsushi Tokunaga. A genome-wide association study of CM-SJS/TEN in Japanese population based on whole genome sequencing. Poster, June 15, 2019.
  6. 2019 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), 27th April ~ 3rd May, 2019, in Vancuver, Canada
      Keiko Yokoi, Norihiko Yokoi, Mayumi Ueta, and Chie Sotozono. The Treatment Effect of 0.1% Tacrolimus Eye Drops in Young and Elder Vernal Keratoconjunctivitis Patients. Poster
  7. SJS/TEN 2019, Vancuver Canada April 25-26th, 2019
    Hiroki Mieno, Kaori Matsumoto, Mayumi Ueta, Chie Sotozono. Corticosteroid Pulse Therapy and Ophthalmological Intervention from the Early Onset of SJS/TEN. SJS/TEN 2019, Vancuver Canada April 25-26th, 2019.
  8. American Society of Human Genetics (ASHG), San Diego, United States., 19 October 19th, 2018.
    Ken Nakatani, Seik-Soon Khor, Yuki Hitomi, Mayumi Ueta, Yuko Okudaira, Anri Masuya, Yuki Wada, Chie Sotozono, Shigeru Kinoshita, Hidetoshi Inoko, Katsushi Tokunaga. Exploration of disease susceptibility HLA alleles for cold medicine-related Stevens-Johnson syndrome with high resolution NGS-based HLA typing. American Society of Human Genetics (ASHG), San Diego, United States., 19 October 19th, 2019. poster 2246F
  9. 2019 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting, San Francisco, USA, 24 Feb, 2019.
    Risa Tamagawa-Mineoka, Naomi Nakamura, Mayumi Ueta, Eiichi Konishi, Risa Yasuike, Koji Masuda, Hiroshi Matsunaka, Yumi Murakami, Emiko Yokosawa, Norito Katoh, Elevated expressions of stratum corneum Toll-like receptor 3 in atopic dermatitis lesions, 2019 American Academy of Allergy, Asthma & Immunology (AAAAI) Annual Meeting, San Francisco, USA, poster 398, 24 Feb, 2019.
  10. 34th Congress of Asia-Pacific Academy of Ophthalmology, Bangkok, Thailand, 7-9 March 2019.
    Mayumi Ueta, Chie Sotozono, Hiromi Nishigaki, Suzuko Ohsako, Norihiko Yokoi, Shigeru Kinoshita. Upregulation of Teneurin-2 transcript in the conjunctival epithelium of Stevens-Johnson syndrome patients in the chronic stage, 34th Congress of Asia-Pacific Academy of Ophthalmology, Bangkok, Thailand, Poster No.: EX1-033, 7 March 2019. Hiroki Mieno, Mayumi Ueta, Keiko Yamada, Akihide Watanabe, Shigeru Kinoshita, and Chie Sotozono. The expression of prostaglandin E2 receptor 3 in the eyelid epidermis of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis. Rapid Fire Cornea, External Eye Diseases & Eye Banking Update Session 2, free paper (oral) 6, 9 March 2019.
  11. 2018 American Academy of Ophthalmology, Chicago, USA, 27-30th Oct, 2018.
    Mayumi Ueta, Passara Jongkhajornpong, Tais H. Wakamatsu, Chitra Kannabiran, Kaevalin Lekhanont, Jose Alvaro P. Gomes, Virender Sangwan, Chie Sotozono, Shigeru Kinoshita. Cold medicine related Stevens-Johnson syndrome Associated with HLA-B*44:03 in various ethnic populations. PO348.
  12. ISER 2018 (XXIII Biennial Meeting of the International Society for Eye Research) in Belfast, UK, September 10th, 2018, poster 5.
    Mayumi Ueta, Hiromi Nishigaki, Chie Sotozono, Suzuko Ohsako, Norihiko Yokoi, Shigeru Kinoshita, Gene Expression Analysis of conjunctival epithelium of Stevens-Johnson syndrome patients in the chronic stage, poster 5.
  13. The European Academy of Allergy and Clinical Immunology (EAACI) Congress 2018 in Munchen, Germany, May 29th, 2018.
    Mayumi Ueta, Hiromi Nishigaki, Suzuko Ohsako, Shigeru Kinoshita. Regulation of Ikzf1 inducible genes in epidermis, oral, Oral Abstract Session (OAS) 34-5.
  14. 2018 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), 29th April ~ 3rd May, 2018, in Hawai, USA
    Mayumi Ueta, Hiromi Nishigaki, Kiyoko Oosako, Shigeru Kinoshita. Regulation of Ikzf1 inducible genes by TLR3 and IPS-1. Poster, 2018.4.29 Keiko Yamada, Mayumi Ueta, Hiromi Nishigaki, Norihiko Yokoi, Chie Sotozono, Shigeru Kinoshita. The effects of rebamipide-based gene-expression analysis in human conjunctival epithelial cells. Poster, 2018.4.29
  15. Drug Hypersensitivitiy Meeing 2018, Amsterdam, Netherland, 19th April, 2018.
    Mayumi Ueta, Passara Jongkhajornpong, Tais H. Wakamatsu, Chitra Kannabiran, Kaevalin Lekhanont, Jose Alvaro P. Gomes, Virender Sangwan, Chie Sotozono, Shigeru Kinoshita. Significant Association between HLA-B*44:03 and Cold medicine related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with Severe Ocular complications in various ethnic populations. Poster
  16. Gordon Research Conference 2018 : Cornea and Ocular Surface Biology and Pathology. Defining the Mechanisms Through Which the Cornea, Tear Film and Immune System Operate Under Pathological Conditions, Ventura, CA, US. February 18 - 23, 2018.
    Mayumi Ueta, Suzuko Ohsako, Shigeru Kinoshita. Regulation of CD11c positive cells by TLR3 in the cornea. poster, Feb 18 - 23, 2018.
  17. The 33rd Asia-Pacific Academy of Ophthalmology (APAO) Congress, HongKong, China, February 9, 2018.
    Chitra Kannabiran, Mayumi Ueta, Virender Sangwan, Varsha Rathi, Sayan Basu, Katsushi Tokunaga, Shigeru Kinoshita. Association of Human Leukocyte Antigen Class 1 genes with Stevens Johnson Syndrome with severe ocular complications in an Indian population. Oral.
  18. 2017 American Academy of Ophthalmology, NewOrleans, USA, 11-14th Nov, 2017.
    Yamato Yoshikawa, Mayumi Ueta, Tsutomu Inatomi, Norihiko Yokoi, Shigeru Kinoshita, Kensuke Tajiri, Tsunehiko Ikeda, Chie Sotozono. Long-term clinical course of Stevens-Johnson syndrome with ocular sequelae, P0064, 11-12th Nov Hideki Fukuoka, Miho Sasaki, Yoshitsugu Inoue, Kohji Nishida, Kazuo Tsubota, Yuichi Oohashi, Eiji Nakatani, Hideaki Kaneda, Masanori Fukushima, Mayumi Ueta, Shigeru Kinoshita, Chie Sotozono. Treatments and complications of Mooren’s ulcer from National Survey in Japan P0053, 11-12th Nov
  19. The American Society of Human Genetics (ASHG) 2017, Orland, USA, Oct 18-19, 2017.
    Mayumi Ueta, Katsushi Tokunaga, Chikara Inoue, Hiromi Sawai, Chie Sotozono, Shigeru Kinoshita, Trial to make the combined genotyping to detect high-risk individuals for cold medicine related Stevens-Johnson syndrome (CM-SJS) with Severe Ocular Complications (SOC), poster Khor SS, Hitomi Y, Okudaira Y, Masuya A, Ozaki Y, Ueta M, Nakatani K, Nagato M, Ogawa T, Sotozono C, Kinoshita S, Inoko H, Tokunaga K: “Evaluation of NXTypeTM NGS high-resolution HLA typing kit, poster
  20. The XXXV Congress of the European Society of Cataract and Refractive Surgeons (ESCRS) 2017, Oct 7-10, 2017.
    Mayumi Ueta, Hiromi Nishigaki, Chie Sotozono, Shigeru Kinoshita, Differences of the tear cytokines between atopic keratoconjunctivitis and chronic Stevens-Johnson syndrome, poster
  21. The American Society for Histocompatibility and Immunogenetics, San Francisco, CA, Sep. 12,2017.
    Khor SS, Hitomi Y, Okudaira Y, Masuya A, Ozaki Y, Ueta M, Nakatani K, Nagato M, Ogawa T, Sotozono C, Kinoshita S, Inoko H, Tokunaga K: “Evaluation of NXTypeTM NGS high-resolution HLA typing kit.” The American Society for Histocompatibility and Immunogenetics, San Francisco, CA, poster
  22. The European Academy of Allergy and Clinical Immunology (EAACI) Congress 2017 in Helsinki, June 18th, 2017.
    Mayumi Ueta, Junji Hamuro, Naomi Nakamura,Risa Tamagawa-Mineoka, Norito Katoh, Shigeru Kinoshita. Elevated Expression of Ikaros Family Zinc Finger 1 (IKZF1) Exacerbates Mucocutaneous Inflammation, oral
  23. 2017 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), May 8, 2017, in Baltimore, USA 2017.5.10
    Hiroki Mieno, Mayumi Ueta, Keiko Yamada, Yukito Yamanaka, Tomomichi Nakayama, Akihide Watanabe, Shigeru Kinoshita, Chie Sotozono. The expression of prostaglandin E2 receptor 3 in the eyelid epidermis of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis, poster
  24. The EAACI/ESCD Skin Allergy Meeting, SAM 2017, 27 ? 29 April 2017, Zurich, Switzerland
    Mayumi Ueta, Junji Hamuro, Shigeru Kinoshita, Skin Inflammation of Ikzf1-EGFP Transgenic Mice, poster
  25. Asia Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) 2017, in Brisbane, Australia, Feb 7, 2017.
    Mayumi Ueta, Hiromi Nishigaki, Chie Sotozono, Shigeru Kinoshita. Down-regulation of IP-10 in Tears of Patients in the Chronic Stage of Stevens-Johnson Syndrome.
  26. The American Society of Human Genetics (ASHG) 2016, Vancouver, Canada. Oct 19-20, 2016.
    Mayumi Ueta, Hiromi Sawai, Ryosei Shingaki, Yusuke Kawai, Chie Sotozono, Kaname Kojima, Masao Nagasaki, Shigeru Kinoshita, Katsushi Tokunaga, Genome-wide association study using the Japonica array for cold medicine-related Stevens-Johnson syndrome with severe ocular complications. Khor SS,Zheng XW, Sawai H, Nishida N, Hitomi Y, Ueta M, Shingaki R, Iwata S, Kinoshita S, Tokunaga K. High accuracy HLA alleles imputation system for Affymetrix Axiom Japonica Array? and its application on Steven-Johnson Syndrome.
  27. 2016 American Academy of Ophthalmology,Chicago, USA. 2016. 10. 17.
    Mayumi Ueta, Chie Sotozono, Katuhiko Shinomiya, Norihiko Yokoi, Shigeru Kinoshita.Protein Expression of the Susceptibility Genes for Stevens-Johnson syndrome in the Ocular Surface. Poster
  28. 2015 TFOS (8th International Conference on the Tear Film & Ocular Surface) Montpellier、France 2015.9.9.
    Mayumi Ueta, Hiromi Nishigaki, Chie Sotozono, Shigeru Kinoshita. Tear Cytokines of Stevens-Johnson syndrome in the chronic stage.
  29. 2016 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO). Seattle, WA, USA. May 3. 2016.
    Mayumi Ueta, Hiromi Nishigaki, Katsuhiko Shinomiya, Norihiko Yokoi, Chie Sotozono, Shigeru Kinoshita. IKZF1 Expression and Upregulation by polyI:C in Human Ocular Surface Epithelial Cells. Tais Hitomi Wakamatsu , Mayumi Ueta, Katsushi Tokunaga, Yukinori Okada, Renata Ruoco Loureiro, Karita Antunes Costa, Juliana Maria Ferraz Sallum, Jose Milhomens, Chie Sotozono, Jose Alvaro Pereira Gomes, Shigeru Kinoshita. HLA class 1 genes associated with Cold Medicine related Stevens-Johnson syndrome in Brazilian patients.
  30. 19th ANNUAL IOSS (International Ocular Surface Society) MEETING. Seattle, WA, USA. April 30. 2016.
    Mayumi Ueta, Chie Sotosono, Shigeru Kinoshita. Stevens-Johnson syndrome with severe ocular surface complications might be associated with disordered innate immune response.
  31. The 7th International Drug Hypersensitivity Meeting, Malaga, Spain 22 April 2016.
    Mayumi Ueta, Hiromi Sawai, Chie Sotozono, Katushi Tokunaga, Shigeru Kinoshita. Genetic Predisposition of Cold medicine related SJS/TEN with severe ocular complications.
  32. The 13th International Congressof Human Genetics. Kyoto, Japan 5 April 2016.
    Mayumi Ueta, Hiromi Sawai, Junji Hamuro, Yuki Hitomi, Chie Sotozono, Katsushi Tokunaga, Shigeru Kinoshita. Regulation of Mucocutaneous Inflammation by Cold Medicine?Related Stevens-Johnson Syndrome susceptibility gene, IKZF1. Khor SS, Hitomi Y, Ueta M, Sawai H, Zawlatt K, Sotozono C, Kinoshita S, Tokunaga K. Comprehensive exploration of the high-risk rare variants for the cold medicine?related Stevens-Johnson syndrome/ toxic epidermal necrolysis (CM-SJS/TEN) with Severe Ocular complications by whole-exome sequencing.
  33. Keystone Symposium Immunity in Skin Development, Homeostasis and Disease . Tahoe City, California, USA. 1 March 2016.
    Mayumi Ueta, Hiromi Nishigaki, Shigeru Kinoshita. IKZF1 Expression and Upregulation by polyI:C in Human Epidermal Keratinocytes.
  34. 2015 American Academy of Ophthalmology, LasVegas, USA. 2015. 11. 14-15.
    Mayumi Ueta, Katsushi Tokunaga, Chie Sotozono, Hiromi Sawai, Shigeru Kinoshita. Contribution of combination of multiple gene polymorphisms to the onset of cold medicine-related Stevens-Johnson syndrome with severe ocular complications. Poster Chie Sotozono, Mayumi Ueta, Eiji Nakatani, Hideaki Kaneda, Masanori Fukushima, Yoko Kano, Tetsuo Shiohara, and Shigeru Kinoshita. Predictive Factors Associated with Long-Term Ocular Sequelae of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Poster.
  35. European Association for Vision and Eye Research (EVER) 2015, Nice, France, 2015. 10. 7.
    Ueta M, Tokunaga K, Sotozono C, Sawai H, Yoon KC, Kim MK, Seo KY, Joo CK, Kinoshita S. HLA-A*02:06 and PTGER3 polymorphism exerts additive effects in cold medicine-related Stevens-Johnson syndrome with severe ocular complications in Japanese and Korean populations. (oral)
  36. Allergy School e-PAD: EAACI Practical Allergy Diagnosis,Moscow, Russia, 2015. 8.27.
    Ueta M, Shoji J, Sotozono C, Kinoshita S: Tear Markers for Atopic Keratoconjunctivitis.
  37. The European Academy of Allergy and Clinical Immunology (EAACI), Barcelona, Spain, 2015.6.9.
    Ueta M, Tokunaga T, Sotozono C, Sawai H, Kinoshita S: HLA-A*02:06 and PTGER3 polymorphism exerts additive effects in cold medicine-related Stevens-Johnson syndrome with severe ocular complications. (oral)
  38. 2015 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO). Denver, CO, USA. May 3,5,7. 2015.
    Tais H.Wakamatsu, Mayumi Ueta, Renata R. Loureiro, Karita A.Costa, Juliana M.Sallum, Chie Sotozono, Shigeru Kinoshita, Jose A.Gomes. Association of HLA-B*44:03 with Stevens-Johnson syndrome in Brazilian patients. Mayumi Ueta, Chie Sotozono, Hiromi Sawai, Katsushi Tokunaga, Shigeru Kinoshita. PTGER3 SNPs associated with Cold Medicine?Related Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis with Severe Ocular complications. Katsuhiko Shinomiya, Mayumi Ueta, Shigeru Kinoshita. The characteristics of a dry-eye mouse model produced by exorbital and intraorbital lacrimal gland excision and histological changes in the ocular surface of that model.
  39. 18th ANNUAL IOSS (International Ocular Surface Society) MEETING. Denver, CO, USA. May 2. 2015.
    Mayumi Ueta, Jun Shoji, Chie Sotozono, Shigeru Kinoshita. Anti-inflammatory Effects of Rebamipide Eyedrops on Allergic Conjunctival Disease.
  40. Mayumi Ueta, Jun Shoji, Chie Sotozono, Shigeru Kinoshita. Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. 2015 Asia-ARVO, Yokohama, Japan, Feb 18, 2015.
  41. Mayumi Ueta, Hiromi Sawai, Chie Sotozono, Yuki Hitomi, Nahoko Kaniwa, Mee Kum Kim, Kyoung Yul Seo, Kyung-Chul Yoon, Choun-Ki Joo, Chitra Kannabiran, Tais Hitomi Wakamatsu, Virender Sangwan, Varsha Rathi, Sayan Basu, Takeshi Ozeki, Taisei Mushiroda, Emiko Sugiyama, Keiko Maekawa, Ryosuke Nakamura, Michiko Aihara, Kayoko Matsunaga, Akihiro Sekine, José Álvaro Pereira Gomes , Junji Hamuro, Yoshiro Saito, Michiaki Kubo, Shigeru Kinoshita, Katsushi Tokunaga. New Susceptibility Gene IKZF1 for Cold Medicine–Related Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis with Severe Mucosal Involvement. The American Society of Human Genetics (ASHG) 2014, San Diego, CA, USA. Oct 21, 2014.
  42. Hitomi Y, Khor SS, Ueta M, Sotozono C, Kinoshita S, Tokunaga K. Whole exome sequencing of Cold Medicine–Related Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (CM-SJS/TEN) with Severe Mucosal Involvement. The American Society of Human Genetics (ASHG) 2014, San Diego, CA, USA. Oct 20, 2014.
  43. Hiromi Sawai, Mayumi Ueta, Yuki Hitomi, Chie Sotozono, Shigeru Kinoshita, Katsushi Tokunaga. Search for new risk gene for Stevens-Johnson Syndrome independent of HLA risk allele. The American Society of Human Genetics (ASHG) 2014, San Diego, CA, USA. Oct 21, 2014.
  44. Mayumi Ueta, Jun Shoji, Chie Sotozono, Norihiko Yokoi, Shigeru Kinoshita. Suppressive effects of IL-8, ECP and total IgE in the tear of atopic keratoconjunctivitis by rebamipide eye drops. The European Academy of Allergy and Clinical Immunology  Congress 2014(EAACI 2014), Copenhagen, Denmark, June 10, 2014.
  45. Mayumi Ueta, Chie Sotozono, Shigeru Kinoshita. HLA markers of   cold medicine-related  Stevens-Johnson syndrome with severe mucosal involvements in the Japanese. 2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Orland, FL, USA, 2014.5.7.
  46. Mayumi Ueta, Ayaka Koga, Masaru Ishii, Shigeru Kinoshita. Analysis of the Cellular Dynamics of LysM-Positive Cells in a Corneal Suture Mouse Model using Intravital Imaging. Imaging Conference 2014 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Orland, FL, USA, 2014.5.3.
  47. Mayumi Ueta, Chie Sotozono, Hiromi Sawai, Katsushi Tokunaga, Shigeru Kinoshita. Strong association between HLA-A*02:06 and Acetaminophen-related Stevens-Johnson syndrome with severe mucosal involvements in the Japanese. The 6th International Drug Hypersensitivity Meeting, Bern, Switzerland 10 April 2014.
  48. Ryosuke Nakamura, Nahoko Kaniwa, Mayumi Ueta, Chie Sotozono, Emiko Sugiyama, Keiko Maekawa, Akiko Yagami, Setsuko Matsukura, Zenro Ikezawa, Kayoko Matsunaga, Tokunaga Katsushi, Michiko Aihara, Shigeru Kinoshita, Yoshiro Saito. HLA association with antipyretic analgesics-induced Stevens-Johnson syndrome / toxic epidermal necrolysis with severe ocular surface complications in Japanese patients. The 6th International Drug Hypersensitivity Meeting, Bern, Switzerland 10 April 2014.
  49. Nahoko Kaniwa, Mayumi Ueta, Ryosuke Nakamura, Emiko Sugiyama, Keiko Maekawa, Yukitoshi Takahashi, Hirokazu Furuya, Akiko Yagami, Setsuko Matsukura, Zenro Ikezawa, Kayoko Matsunaga, Chie Sotozono, Michiko Aihara, Shigeru Kinoshita, Yoshiro Saito. Medication tendencies for inducing severe ocular surface symptoms in Japanese Stevens-Johnson syndrome / toxic epidermal necrolysis patients. The 6th International Drug Hypersensitivity Meeting, Bern, Switzerland 10 April 2014.
  50. Mayumi Ueta, Jun Shoji, Chie Sotozono, Norihiko Yokoi, Shigeru Kinoshita. Anti-inflammatory effects of rebamipide eye drops on allergic conjunctivitis with and without giant papillae. 2014 World Ophthalmology Congress of the International Council of Ophthalmology. Tokyo, Japan, 2 April 2014.
  51. Yuriko Ban, Junko Tsujimoto, Keiko Yamada, Mayumi Ueta, Shigeru Kinoshita. The Change of the Barrier Function in hTERT Immortalized Corneal and Conjunctival Epithelia by Poly(I:C) Challenge. 2014 World Ophthalmology Congress of the International Council of Ophthalmology. Tokyo, Japan, 2 April 2014.
  52. Ueta M, Mizushima K,Naito Y, Narumiya S, Kinoshita S. Suppression of polyI:C-inducible gene expression by EP3 in murine conjunctival epithelium. ISMA  International Symposium on Molecular Allergology (ISMA) 2013, Vienna、Austria, 2013.12.5.
  53. Ueta M, Sotozono C, Tokunaga K, Kinoshita S: HLA MARKERS OF COLD MEDICINE RELATED STEVENS-JOHNSON SYNDROME. 8th International Cutaneous ADR Congress (ISCAR 2013), 桃園、台湾、2013. 11.17.
  54. Ueta M, Sotozono C, Kinoshita S: HLA analysis of cold medicine related Stevens-Johnson syndrome with ocular complication in Japan. 2013 Annual Meeting of the Asian Association for Research in Vision and Ophthalmology (Asian ARVO), New Delhi, India,2013.10.29.
  55. Ueta M, Sotozono C, Koga A, Yokoi N, Kinoshita S: Anti-inflammatory effects of rebamipide eye drops on allergic conjunctivitis. 2013 TFOS (7th International Conference on the Tear Film & Ocular Surface) Taormina, Sicily、Italy 2013.9.20
  56. Ueta M, Sotozono C, Yokoi N, Kinoshita K. The effect of rebamipide eye drops on allergic conjunctivitis with giant papilla. The EAACI (European Academy of Allergy and Clinical Immunology)-WAO (World Allergy Organization)  Congress 2013, Milano, Italy 2013.6.25
  57. Ueta M, Narumiya S, Kinoshita S: Suppression of TLR3-Inducible Gene Expression by EP3 in Conjunctival Epithelium. 2013 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Seattle, Washington, USA, 2013.5.6.
  58. Koga A, Ueta M, Ishii M, Minamiyama R, Koizumi N, Kinoshita S: Kinetic analysis of neutrophils in a corneal-alkali-injury mouse model. 2013 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Seattle, Washington, USA, 2013.5.6.
  59. Ueta M, Sotozono C, Yokoi N, Kinoshita S: Anti-inflammatory effect of rebamipide on the ocular surface. XX Biennial Meeting of the International Society for Eye Research, Leuven, Belgium, 2013.3.21.
  60. Koga A, Ueta M, Ishii M, Koizumi N, Kinoshita S: Kinetic analysis of neutrophils in a corneal-alkali-injury mouse model. The 28th Asia-Pacific Academy of Ophthalmology Congress held in conjunction with the 71th Annual Conference of All India Ophthalmological Society (APAO-AIOS 2013), Hyderabad, India. 2013.1.18.
  61. Shinomiya K, Ueta M, Sotozono C, Inatomi T, Yokoi N, Koizumi N, Kinoshita K: Immunohistochemical analysis of inflammatory limbal conjunctiva adjacent to Mooren’s ulcer. The 28th Asia-Pacific Academy of Ophthalmology Congress held in conjunction with the 71th Annual Conference of All India Ophthalmological Society (APAO-AIOS 2013), Hyderabad, India. 2013.1.17.
  62. Ueta M, Sotozono C, Yokoi N, Kinoshita S: Rebamipide Suppresses PolyI:C-Stimulated Cytokine Production in Human Conjunctival Epithelial Cells. XX Biennial Meeting of the International Society for Eye Research, Berlin, Gemany, 2012.7.23.
  63. Ueta M, Matsuoka T, Narumiya S, Akira S, Kinoshita S: EP3 Negatively Regulates TLR3 dependent eosinophilic infiltration of allergic conjunctivitis. European Academy of Allergy and Clinical Immunology Congress 2012, Geneva, Switzerland, 2012.6.17.
  64. Ueta M, Tokunaga K, Sotozono C, Sawai H, Tamiya G, Inatomi T, Kinoshita S: HLA-A*0206 and TLR3 SNPs are jointly predisposed with more than an additive effect to stevens-johnson syndrome with severe ocular complications. 16th International HLA and Immunogenetics Workshop, Liverpool, U.K. 2012.6.1.
  65. Ueta M, Matsuoka T, Narumiya S, Akira S, Kinoshita S: Epistatic interaction between TLR3 and ptger3 genes in experimental allergic conjunctivitis. 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2012.5.8.
  66. Yamada K, Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S: Toll-like receptor subtype Tlr5 expression in human conjunctival epithelium in various cicatricial corneal conjunctival disorders. 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2012.5.8.
  67. Koga A, Ueta M, Ishii M, Koizumi N, Kinoshita S: Analysis of neutrophil dynamics in the cornea after alkali injury using lysm-gfp mice. 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2012.5.8.
  68. Shinomiya K, Ueta M, Kobori M, Nakanishi K, Yokoi N, Kinoshita S: Usefulness of a dry-eye mouse model produced by exorbital lacrimal gland excision and analysis of the increase of caspase-1 independent IL-1 β in the tear fluid of those mice. 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2012.5.7.
  69. Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M,Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Kinoshita S: Epistatic interaction between TLR3 and PTGER3 confers an increased risk for Stevens-Johnson syndrome with ocular complications. 2012 Gordon Research Conference:Biology & Pathobiology of the Cornea, Ventura, California, USA, 2012.3.28.
  70. Ueta M: Up-regulation of RIG-I and MDA5 by polyI:C stimulation in human ocular surface epithelial cells. EAACI/GA2LEN Allergy School Clinical Impact and Mechanisms of Infections in Allergy, Edinburgh, UK, 2011.9.17.
  71. Ueta M, Yokoi N, Kinoshita S: Prostaglandin E2 suppresses polyI:C-stimulated cytokine production via EP2 and EP3 in human ocular surface epithelial cells. The European Academy of Allergy and Clinical Immunology (EAACI), Istanbul, Turkey, 2011.6.12.
  72. Yamada K, Ueta M, Sotozono C, Yokoi N, Inatomi T, Koizumi N, Kinoshita S: Prostaglandin E receptor subtype Ep4 expression in human conjunctival epithelium and its changes in various ocular surface disorders. 2011 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2011.5.4.
  73. Imai K, Ueta M, Mori K, Ikeda Y, Ueno M, Yokoi N, Koga T, Narumiya S, Kinoshita S: FP localization and expression in ocular tissue. 2011 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2011.5.4.
  74. Ueta M, Matsuoka T, Yokoi N, Kinoshita S: Prostaglandin E2 suppresses polyi:c-stimulated cytokine production via EP2 and EP3 in human conjunctival epithelial cells. 2011 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2011.5.3.
  75. Ueta M, Sotozono C, Tokunaga K, Tamiya, Nakaji S, Inatomi T, Kinoshita S: HLA-A*0206 and the TLR3 polymorphism jointly predispose to Stevens-Johnson syndrome with ocular complications. The 2nd Asia Cornea Society Biennial Scientific Meeting, Kyoto, JAPAN, 2010.12.2.
  76. Ueta M, Yokoi N, Uematsu S, Kawai T, Akira S, Kinoshita S: The expression and function of RIG-I and MDA-5 in human ocular surface epithelium. the 6th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance, Florence, Italy, 2010.9.23.
  77. Ueta M, Sotozono C, Nakano M, Taniguchi T, Yagi T, Tokuda Y, Fuwa M, Inatomi T, Yokoi N,  Tashiro K, Kinoshita S: Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome with ocular involvement identified by genome-wide association study in a Japanese population. Keystone Symposia, Bioactive Lipids, Biochemistry and Diseases, Kyoto, JAPAN, 2010.6.9.
  78. Ban Y, Tsujimoto J, Ueta M, Yokoi N, Kinoshita S: Poly(I:C) challenge strengthens the barrier function in hTERT immortalized corneal and conjunctival epithelia. 2010 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2010.5.3.
  79. Sotozono C, Ueta M, Inatomi T, Kinoshita S: Chronic ocular complications in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis 4th International Drug Hypersensitivity Meeting, Roma, Italy, 2010.4.22.
  80. Ueta M, Sotozono C, Inatomi T, Kinoshita S: Genetic factors of Stevens-Johnson syndrome with ocular complications in Japanese. 4th International Drug Hypersensitivity Meeting. Roma, Italy, 2010.4.22.
  81. Ueta M, Mizushima K, Yokoi N, Naito Y, Kinoshita S: Gene expression analysis of polyI:C-stimulated primary human conjunctival epithelial cells. Gordon Research Conferences, Biology & Pathobiology of the Cornea, Ventura, California, USA, 2010. 3. 10.
  82. Ueta M, Uematsu S,Akira S, Kinoshita S: Toll-like receptor 3 regulates late-phase reaction of experimental allergic conjunctivitis. 14th international congress of mucosal immunology (ICMI2009) Boston, Massachusetts, USA. 2009.7.7.
  83. Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S: EP3 expression and functions in human ocular surface epithelium. 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2009.5.6.
  84. Kinoshita S, Ueta M, Sotozono C, Inatomi T, Nakano M, Yagi T, Taniguchi T, Fuwa M, Tokuda Y, Tashiro K: EP3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome. 2009 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2009.5.6.
  85. Ueta M, Sotozono C, Inatomi T, Kinoshita S: Association of Toll-like receptor 3 gene polymorphisms with Stevens-Johnson syndrome. Keystone Symposia, Pattern Recognition Molecules and Immune Sensors of Pathogens, Banff, Alberta, Canada. 2009. 4. 2.
  86. Ueta M, Matsuoka T, Narumiya S, Kinoshita S: Prostaglandin E receptor subtype EP3 in mouse conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis. Keystone Symposia, allergy and asthma. Keystone, Colorado, USA. 2009. 1. 24.
  87. Sotozono C, Ueta M, Koizumi N, Inatomi T, Kinoshita S: Importance of ocular findings for the early diagnosis of Stevens-Johnson syndrome. 2008 American Academy of Ophthalmology, Atlanta, USA. 2008. 11. 10.
  88. Ueta M, Sotozono C, Inatomi T, Kinoshita S: Genetic factors of Stevens-Johnson syndrome in Japanese. 2008 American Academy of Ophthalmology, Atlanta, USA, 2008. 11. 10.
  89. Ueta M, Matsuoka T, Narumiya S, Kinoshita S: Regulation of murine experimental allergic conjunctivitis late-phase reaction by prostaglandin E receptor subtype EP3. ISOCB Conference 2008, San Diego, California, USA, 2008.9.2-5.
  90. Ueta M, Sotozono C, Inatomi T, Hamuro J, Kinoshita S: Association of Fas Ligand gene polymorphism with Stevens-Johnson syndrome. World Ophthalmology Congress (WOC) 2008, Hong Kong, 2008. 7.29.
  91. Sotozono C, Araki Y, Inatomi T, Ueta M, Yokoi N, Kinoshita S: Successful treatment of Stevens-Johnson syndrome with high-dose corticosteroid pulse therapy at disease onset. 2008 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2008.4.28.
  92. Ueta M, Sotozono C, Inatomi T, Hamuro J, Kinoshita S: Association of combined IL-13/IL-4R signaling pathway gene polymorphismwith Stevens-Johnson syndrome. 2008 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2008.4.28.
  93. Kojima K, Ueta M, Hozono Y, Hamuro J, Kinoshita S: Human ocular surface epithelial cells express TLR5 and respond to bacterial flagellin. 13 th International Congress of Mucosal Immunology, Tokyo, JAPAN, 2007. 7.10.
  94. Ueta M, Sotozono C, Inatomi T, Kojima K, Tashiro K, Hamuro J, Kinoshita S: Toll like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome. 13 th International Congress of Mucosal Immunology, Tokyo, JAPAN, 2007. 7.10.
  95. Sotozono C, Ueta M, Koizumi N, Hibino S, Inatomi T, Kinoshita S: Acute conjunctivitis as the initial symptom of Stevens-Johnson syndrome with ocular complications and the consequence of topical steroids. 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2007.5.6.
  96. Kojima K, Ueta M, Hamuro J, Yokoi N, Kinoshita S: Expression and function of TLR2 in human conjunctival epithelial cells. 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2007.5.10.
  97. Ueta M, Sotozono C, Inatomi T, Hamuro J, Kinoshita S: Gene expression analysis of monocytes derived from the patients of Stevens-Johnson syndrome with ocular complications. 2007 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2007.5.6.
  98. Hozono Y, Ueta M, Hamuro J, Kinoshita S: Human corneal epithelial cells respond to ocular pathogenic, but not to non-pathogenic bacterial flagellin. 2006 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2006.5.1.
  99. Kojima K, Ueta M, Hozono Y, Hamuro J, Kinoshita S: Response to human corneal epithelial cells to various toll-like receptor 2 ligands. 2006 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2006.5.1.
  100. Ueta M, Hamuro J, Ueda E, Yamamoto M, Akira S, Kinoshita S: Spontaneous ocular surface inflammation in IkappaBzeta gene-disrupted mice. 2006 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2006.5.3.
  101. Ueta M, Iida T, Sakamoto M, Sotozono C, Takahashi J, Okada K, Kinoshita S, Honda T: Polyclonality of staphylococcus epidermidis on healthy ocular surface  4th international conference on ocular infections JAPAN, Hokkaido, Japan, 2005. 10.2.
  102. Ueta M, Hamuro J, Kiyono H, Kinoshita S: Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. 12th International Congress of Mucosal Immunology, Boston, Massachusetts, USA, 2005. 6. 29.
  103. Ueta M, Sotozono C, Sakamoto M, Takahashi J, Okada K, Honda T, Kinoshita S: Meaning of staphylococcus epidermidis residing on ocular surface. World Cornea Congress V, Washington DC, USA, 2005.4.14.
  104. Ueta M, Hamuro J, Yamamoto M, Akira S, Kinoshita S: Spontaneous ocular surface inflammation and goblet cell disapperance in IkBz gene-disrupted mice. 2005 Keystone Symposia, Innate Immunity to Pathogens, Steamboat Springs, Colorado, USA, 2005.1.11.
  105. Ueta M, Hamuro J, Kinoshita S: Expression of NF-kB negative regulators on ocular surface. 2004 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida, USA, 2004.4.29.
  106. Ueta M, Jang MH, Kawasaki S, Shikina T, Hiroi T, Kinoshita S: Expression and function of TLRs in human ocular surface epithelium. 2003 American Association of Immunologists 90th Anniversary Annual Meeting (AAI) Denver,  Colorado, USA, 2003.5.7.
  107. Ueta M, Jang MH, Kawasaki S, Shikina T, Hiroi T, Kinoshita S: Expression and function of TLRs in human ocular surface epithelium. 2003 Keystone Symposia, The Regulation of Mucosal Inflammation, Keystone Colorado, USA, 2003.4.4.
  108. Ueta M, Sano Y, Sotozono C, Yamada J, Koizumi N, Kinoshita S: Immunosuppressive properties of human amniotic membrane. 2001 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Fort Lauderdale, Florida,USA, 2001.5.1.

Research

Genetic predisposition of Stevens-Johnson Syndrome with Severe ocular surface complications

Stevens-Johnson syndrome (SJS) is an acute inflammatory vesiculobullous reaction of the skin and mucosa, such as the ocular surface, oral cavity, and genitals. In patients with extensive skin detachment and a poor prognosis, the condition is called toxic epidermal necrolysis (TEN). In the acute stage, patients manifest vesiculobullous lesions of the skin and mucosa, severe conjunctivitis, and ocular surface epithelial defects. In the chronic stage, despite the healing of the skin lesions, severe ocular surface complications persist such as severe dry eye, symblepharon, trichiasis, conjunctival invasion into the cornea and sometimes result in visual disturbance.

This proceeding consists of three subject, first subject is“Position of ophthalmic SJS”, second subject is “HLA analysis”, third subject is “Genome wide association study”, and forth subject is “other findings”.

1. Position of ophthalmic SJS

Diagnostic criteria for SJS in Japan 1.
Major Criteria consist of three findings; 1. Severe, hyperemic and/or hemorrhagic mucocutaneous lesions, 2. Epidermal detachment involves less than 10% of the total body surface area, 3. High fever (>38.0℃). The definite diagnosis of SJS need these all 3 major findings, which include mucosal lesions

Diagnostic criteria for TEN in Japan 1.
Major Criteria consist of three fondings; 1. Epidermal detachment involves more than 10% of the total body surface area, 2. Exclusion of staphylococcal scalded skin syndrome, 3. High fever (>38.0℃). The definite diagnosis of TEN need these all 3 major findings but they do not include mucosal lesions. So, some, not all, of TEN might have mucosal lesions.

Thus, SJS/TEN with mucosal lesion consist of SJS and a part of TEN. Moreover, not all, but some of SJS/TEN with mucosal lesions complicate severe ocular lesion such as severe conjunctivitis with psedomembrane and ocular surface epithelial defects. Furthermore, dermatologists see patients only in their acute stage. On the other hand, ophthalmologists encounter SJS/TEN patients not only in the acute stage but also in the chronic stage. So, it is difficult for ophthalmologists to render a differential diagnosis of SJS or TEN when patients present in the chronic stage because the vesiculobullous skin lesion expressed in the acute stage have healed by the chronic stage. Thus, ophthalmologists tend to report both SJS and TEN with severe ocular complications as “SJS” in a broad sense (Fig.1) 2. Our diagnosis of SJS/TEN (SJS in the broad sense) was based on a confirmed history of acute-onset high fever, serious mucocutaneous illness with skin eruptions, and involvement of at least 2 mucosal sites including the ocular surface.

Short summary is “Ophthalmic lesions appear in not all, but some of SJS/TEN patients who were diagnosed by dermatologists.”

2. HLA analysis
SJS/TEN are rare, but often associated with inciting drugs. Some causative drugs were reported, and some associations between HLA type and the drugs have also been reported. SJS/TEN induced by Allopurinol, a uric acid-lowering drug, was strongly associated with HLA-B* 58:01 in Han Chinese 3, Caucasian 4, and Japanese patients 5(Fig. 2). SJS/TEN induced by Carbamazepine, an anticonvulsant, was strongly associated with HLA-B*15:02 in Han Chinese 6, and HLA-A*31:01 in European 7 and Japanese 8(Fig. 2).
We have reported that cold medicines including NSAIDs and multi-ingredient cold medications were the main causative drugs for SJS/TEN with severe ocular complications 9, 10. About 80% of our patients have developed SJS/TEN after treatment for the common cold 10. Interestingly, allopurinol induces SJS/TEN without severe ocular complications (in submission). Moreover, not all cases of Carbamazepine-induced SJS/TEN have severe ocular complications 11. We performed HLA analysis of cold medicine related SJS/TEN with severe ocular complications (CM-SJS/TEN with SOC).
In Japanese, HLA-A*02:06 was strongly associated with CM-SJS/TEN with SOC, and HLA-B*44:03 also significantly associated with them (Table 1) 9.
Furthermore, compared to the Japanese CM-SJS/TEN without SOC, the significants remain 9. This result showed that HLA-A*02:06 is strongly associated with the Japanese CM-SJS/TEN with SOC, but not CM-SJS/TEN without SOC.
On the other hands, HLA-A*02:06 and HLA-B*44:03 are not associated with cold medicine unrelated (other medicine related) SJS/TEN with severe ocular surface complications9.
We also examined the association with HLA-A*02:06 and HLA-B*44:03 using other ethnic samples such as Korean, Indian and Brazilian samples. HLA-A*02:06 is also associated with Korean CM-SJS/TEN with SOC, but not Indian and Brazilian (Table2) 12. HLA-B*44:03 is associated with CM-SJS/TEN with SOC in Indian and Brazilian, but not Korean (Table2) 12. Especially in Indian, HLA-B*44:03 is strongly associated, 60% of the patients have HLA-B*44:03, while only 11% of controls have it, and odd’s ratio is 12. In Brazilian, when we focused only brazilian caucasian, 40% of the patients have HLA-B*44:03, while 11% of controls have it, odd’s ration is 6 12.

< TABLE 1 >


< TABLE 2 >


Short summary is “CM-SJS/TEN with SOC was associated with HLA-A*02:06 in Japanese and Korean and HLA-B*44:03 in Japanese, Indian and Brazilian Caucasian.” (Fig. 2).


3. Genome wide association study
We performed a genome-wide association study (GWAS) of CM-SJS/TEN with SOC. We first enrolled Japanese 117 cases and 691 controls. We found that the HLA-A region showed the strongest association with susceptibility to CM-SJS/TEN with SOC. Outside of the HLA region, there were 57 SNPs with p < 10-3 (44 genes) in the allele frequency, and 9 SNPs of them (8 genes) were p < 10-5 13.
We selected 8 SNPs of 6 genes, for which functional TaqMan probe available, for the first replication study. There are 9 SNPs p< 10-5 in GWAS using Japanese samples (KPUM samples), for which functional TaqMan probe available 13. So, we focused the IKZF1 SNPs, we genotyped additional two SNPs of the gene (total 4 SNPs), which were included in the 57 SNPs with p < 10-3 outside of the HLA region in the GWAS 13. In the Korean samples, the 3 SNPs of IKZF1 were significantly associated, in the Indian samples, the 1 SNPs of IKZF1 were significantly associated 13. In the Brazillian samples, there were no significant associations with these IKZF1 SNPs; however, the ORs for these four SNPs with the Brazilian sample set showed the same direction of association as with Japanese samples13. Furthermore, the meta-analysis with Japanese, Korean, Indian and Brazillian samples showed a genome-wide significant association between CM-SJS/TEN with SOC and the IKZF1 SNP (rs4917014 (G vs T), OR = 0.5, p = 8.5×10-11, rs4917129 (C vs T), OR = 0.5, p = 8.1×10-9, rs10276619 (G vs A), OR = 1.8, p = 4.3×10-9) 13. These findings show that IKZF1 may be a universal marker for susceptibility to CM-SJS/TEN with SMI.
Finally, we examined the quantitative ratios of IKZF1 alternative splicing isoforms as functional analysis, and found that the ratio of Ik2/Ik1 was significantly associated with the SNPs of IKZF1 13.These results indicate that the ratio of Ik2/Ik1 may be influenced by IKZF1 SNP.”

Short summary is “We conducted a GWAS for CM-SJS/TEN with SMI in Japanese individuals and performed a replication study with Korean and Indian individuals, and found that IKZF1 SNPs were significantly associated with CM-SJS/TEN with SMI, and that the ratio of Ik2/Ik1 isoform may be influenced by these IKZF1 SNPs.”

4. Other finding
For the past decade, SNPs have been widely used as genetic markers for identifying human disease-susceptibility genes. However, it has become apparent that gene-gene interactions should be considered in addition to major single-locus effects 14. We previously reported that in addition HLA-A*02:06, TLR3 14-16, PTGER3 10, 14, IL-4R 17, 18, FasL 19 and IL-13 18 SNPs showed significant associations with SJS/TEN with severe ocular surface complications (Fig.3) and that HLA-A*02:06 with TLR3 polymorphisms exerted more than additive effects in SJS/TEN with SOC 16 (Fig.4).

Furthermore, we also compared EP3 (protein of PTGER3 gene)expression in SJS and chemical burn. The chemical-burn conjunctival epithelium expressed the EP3 protein, the same as in conjunctivochalasis. However, we could not detect EP3 immunoreactivity in the conjunctival epithelium obtained from SJS, in either the chronic and sub-acute stages (Fig. 5) 20. These findings suggest that EP3 is strongly down-regulated in the conjunctival epithelium of SJS.
Cold medicines including NSAIDs (e.g., ibuprofen and loxoprofen) and cold medicine ingredients (e.g., acetaminophen), which were the main causative drugs for SJS/TEN with severe ocular complications, have the shared effect of down-regulating the production of prostanoid, including PGE2. Because the PGE2-EP3 pathway suppresses inflammation of the ocular surface 21, skin 22 and respiratory tract 23, we suggest that down-regulation of PGE2 by NSAIDs or acetaminophen might deeply contribute to the onset of CM-SJS/TEN with SOC.
Thus, some complicated mechanisms involving HLA-A*02:06, TLR3, EP3 and IKZF1 might contribute the pathogenesis of SJS with SOC (Fig.6).

Moreover, CM-SJS/TEN patients have developed SJS/TEN by taking cold medicines after having a common cold as a result of some viral or mycoplasma infections. We postulate that not only cold medicine, but also an infectious agent, virus or other microbe, could together be important and necessary to trigger the onset of SJS/TEN with SOC. Ueta’s hypothesis about onset of SJS/TEN with SOC is that If a person has no genetic background of SJS/TEN with SOC when some microbial infection happens, he/she has normal immune responses, then takes cold medicine, resulting in cure of the common cold, but If a person has genetic background of SJS/TEN with SOC when some microbial infection happens, he/she has abnormal immune responses, then takes cold medicine, which triggers the onset of SJS/TEN with SOC (Fig.7).

References

  1. Sotozono C, Ueta M, Nakatani E, Kitami A, Watanabe H, Sueki H, et al. Predictive Factors associated with Acute Ocular Involvement in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Am J Ophthalmol in press.
  2. Ueta M, Kinoshita S. Ocular surface inflammation is regulated by innate immunity. Prog Retin Eye Res 2012; 31:551-75.
  3. Hung SI, Chung WH, Liou LB, Chu CC, Lin M, Huang HP, et al. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A 2005; 102:4134-9.
  4. Lonjou C, Borot N, Sekula P, Ledger N, Thomas L, Halevy S, et al. A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics 2008; 18:99-107.
  5. Tohkin M, Kaniwa N, Saito Y, Sugiyama E, Kurose K, Nishikawa J, et al. A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Pharmacogenomics J 2013; 13:60-9.
  6. Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004; 428:486.
  7. McCormack M, Alfirevic A, Bourgeois S, Farrell JJ, Kasperaviciute D, Carrington M, et al. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med 2011; 364:1134-43.
  8. Ozeki T, Mushiroda T, Yowang A, Takahashi A, Kubo M, Shirakata Y, et al. Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population. Hum Mol Genet 2011; 20:1034-41.
  9. Ueta M, Kaniwa N, Sotozono C, Tokunaga K, Saito Y, Sawai H, et al. Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement. Sci Rep 2014; 4:4862.
  10. Ueta M, Sotozono C, Nakano M, Taniguchi T, Yagi T, Tokuda Y, et al. Association between prostaglandin E receptor 3 polymorphisms and Stevens-Johnson syndrome identified by means of a genome-wide association study. J Allergy Clin Immunol 2010; 126:1218-25 e10.
  11. Kaniwa N, Saito Y, Aihara M, Matsunaga K, Tohkin M, Kurose K, et al. HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis. Pharmacogenomics 2008; 9:1617-22.
  12. Ueta M, Kannabiran C, Wakamatsu TH, Kim MK, Yoon KC, Seo KY, et al. Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications. Sci Rep 2014; 4:5981.
  13. Ueta M, Sawai H, Sotozono C, Hitomi Y, Kaniwa N, Kim MK, et al. IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement. J Allergy Clin Immunol 2015.
  14. Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, et al. Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes. J Allergy Clin Immunol 2012; 129:1413-6 e11.
  15. Ueta M, Sotozono C, Inatomi T, Kojima K, Tashiro K, Hamuro J, et al. Toll-like receptor 3 gene polymorphisms in Japanese patients with Stevens-Johnson syndrome. Br J Ophthalmol 2007; 91:962-5.
  16. Ueta M, Tokunaga K, Sotozono C, Sawai H, Tamiya G, Inatomi T, et al. HLA-A*0206 with TLR3 polymorphisms exerts more than additive effects in Stevens-Johnson syndrome with severe ocular surface complications. PLoS One 2012; 7:e43650.
  17. Ueta M, Sotozono C, Inatomi T, Kojima K, Hamuro J, Kinoshita S. Association of IL4R polymorphisms with Stevens-Johnson syndrome. J Allergy Clin Immunol 2007; 120:1457-9.
  18. Ueta M, Sotozono C, Inatomi T, Kojima K, Hamuro J, Kinoshita S. Association of combined IL-13/IL-4R signaling pathway gene polymorphism with Stevens-Johnson syndrome accompanied by ocular surface complications. Invest Ophthalmol Vis Sci 2008; 49:1809-13.
  19. Ueta M, Sotozono C, Inatomi T, Kojima K, Hamuro J, Kinoshita S. Association of Fas Ligand gene polymorphism with Stevens-Johnson syndrome. Br J Ophthalmol 2008; 92:989-91.
  20. Ueta M, Sotozono C, Yokoi N, Inatomi T, Kinoshita S. Prostaglandin E receptor subtype EP3 expression in human conjunctival epithelium and its changes in various ocular surface disorders. PLoS One 2011; 6:e25209.
  21. Ueta M, Matsuoka T, Narumiya S, Kinoshita S. Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis. J Allergy Clin Immunol 2009; 123:466-71.
  22. Honda T, Matsuoka T, Ueta M, Kabashima K, Miyachi Y, Narumiya S. Prostaglandin E(2)-EP(3) signaling suppresses skin inflammation in murine contact hypersensitivity. J Allergy Clin Immunol 2009; 124:809-18 e2.
  23. Kunikata T, Yamane H, Segi E, Matsuoka T, Sugimoto Y, Tanaka S, et al. Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat Immunol 2005; 6:524-31.